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Comparative Study of Remnant Cholesterol, Some Lipid Fractions and FBS Level in Overweight and Obese Participants in South East Nigeria

Nnamdi J. Chinonso, Ubuo K. Amah, Onuegbu J. Anaelechi, Okeke C. Stellarmaris, Oti D. Chukwudi, Iwuagwu G. Obioma, Ikechukwu S. Nwaisaac, Ahams E. Chika

Asian Journal of Research in Biochemistry · pp. 11–19 · Published 5 May 2023

10.9734/ajrb/2023/v12i3235

Abstract

Background: Obesity is one of the characteristics of metabolic disorders, it has been linked to cardiovascular diseases. Remnant cholesterol has been proposed to be a link between obesity and coronary heart disease, thus a risk factor for the development of cardiovascular disease in obese people.  We compared the level of calculated non-fasting remnant cholesterol, fasting and non-fasting lipid profile and fasting blood sugar in overweight, obese and normal weight participants in Nnewi, a town in South East Nigeria. Methods: In this cross-sectional study, a total of 90 apparently healthy obese, overweight and normal weight participants who met the inclusion criteria were randomly enrolled. They were grouped using their body mass index of 18.5 to 24.9 kg/m2 (normal weight), 25 to 29.9 kg/m2 (overweight) and ≥30 kg/m2 (obese). The parameters were analyzed using standard methods. Results: Our results shows that there was progressive increase of remnant cholesterol among the group, this increase has no statistical difference (p>0.05) in the mean calculated remnant cholesterol (mmol/l) between the obese (0.72±0.4), overweight (0.68±0.46), and normal weight (0.50±0.28) participants. The mean fasting Very Low Density Lipoprotein (VLDL) and Triglyceride (TG) (mmol/l) were significantly higher (p<0.05) in overweight compared to normal weight participants (0.76±0.31 vs. 0.47±0.22) and (1.72±0.60 vs. 1.09±0.51) and obese participants (0.82±0.23 vs. 0.47±0.22) and (1.85±0.59 vs. 1.09±0.51) when compared to normal weight participants respectively. FBS levels (mmol/l) were significantly lower in normal weight participants when compared to overweight participants (3.45±0.79 vs. 4.46±1.82) and obese participants (3.46± 0.79 vs. 4.94±1.26). Conclusion: The results obtained from this study demonstrated a progressive increase in the level of remnant cholesterol which was not statistically significant among apparently healthy individuals across the group. Furthermore we did not observed Remnant cholesterol as a sole predictor to obesity which will lead to cardiovascular diseases, with the rising prevalence of obesity in developing country as well as its associated complications and risks.

Remnant cholesterol obesity BMI cardiovascular disease lipid profile

References (36)

  1. 1 Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge [DOI]
  2. 2 Enzymatic Determination of Total Serum Cholesterol [DOI]
  3. 3 Determination of Glucose in Blood Using Glucose Oxidase with an Alternative Oxygen Acceptor [DOI]
  4. 4 Poverty and obesity: the role of energy density and energy costs [DOI]
  5. 5 Cardiovascular disease risk profiles [DOI]
  6. 6 The Epidemiology of Obesity [DOI]
  7. 7 Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study. Implications for treatment. [DOI]
  8. 8 Remnant Cholesterol, Not LDL Cholesterol, Is Associated With Incident Cardiovascular Disease [DOI]
  9. 9 Cholesterol and Coronary Heart Disease: Predicting Risks by Levels and Ratios [DOI]
  10. 10 High-Fat Diet Induces Apoptosis of Hypothalamic Neurons [DOI]
  11. 11 Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study
  12. 12 Remnant cholesterol as a cause of ischemic heart disease: Evidence, definition, measurement, atherogenicity, high risk patients, and present and future treatment [DOI]
  13. 13 Contribution of remnant cholesterol to cardiovascular risk [DOI]
  14. 14 A community-based study of hypertension and cardio-metabolic syndrome in semi-urban and rural communities in Nigeria [DOI]
  15. 15 Remnant Cholesterol, Low-Density Lipoprotein Cholesterol, and Blood Pressure as Mediators From Obesity to Ischemic Heart Disease [DOI]
  16. 16 Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors [DOI]
  17. 17 Remnant Cholesterol Variability and Incident Ischemic Stroke in the General Population [DOI]
  18. 18 The Important Role of Sleep in Metabolism [DOI]
  19. 19 Triglyceride-Rich Lipoproteins and Remnants: Targets for Therapy? [DOI]
  20. 20 Excess body weight. An underrecognized contributor to high blood cholesterol levels in white American men [DOI]
  21. 21 Excess Body Weight [DOI]
  22. 22 Epidemiologic aspects of lipid abnormalities [DOI]
  23. 23 Obesity epidemic has emerged among Nigerians [DOI]
  24. 24 Prevalence and epidemiological determinants of metabolically obese but normal-weight in Chinese population [DOI]
  25. 25 Prevalence and Clinical Correlates of Metabolic Syndrome in Nigerians Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome [DOI]
  26. 26 Underweight, overweight and obesity in adults Nigerians living in rural and urban communities of Benue State [DOI]
  27. 27 Association of Increased Remnant Cholesterol and the Risk of Coronary Artery Disease: A Retrospective Study [DOI]
  28. 28 Evidence for an independent relationship between plasma insulin and concentration of high density lipoprotein cholesterol and triglyceride [DOI]
  29. 29 Prevalence of obesity, overweight and proteinuria in an urban community in South West Nigeria
  30. 30 Age-Specific Impact of Obesity on Prevalence and Costs of Diabetes and Dyslipidemia [DOI]
  31. 31 Preanalytical Variables and Biological Variation [DOI]
  32. 32 A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup [DOI]
  33. 33 Pattern of renal impairment among hypertensive subjects in Umuahia, South East, Nigeria [DOI]
  34. 34 Assessment of insulin resistant and the related cardio-metabolic factors in overweight-obese women presented with missed abortion, Baghdad, Iraq [DOI]
  35. 35 Comparative Study of the Level of Atherogenic Markers; Remnant Cholesterol, Non-HDLc, Total Cholesterol-HDLc Ratio and LDLc-HDLc Ratio, in Overweight and Obese Subjects in Nnewi South East Nigeria
  36. 36 INDIAN JOURNAL OF MEDICAL BIOCHEMISTRY [DOI]

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