Comparative Effect of Type 1 and Type 2 Diabetes Mellitus on Vascular Responses of Rat Thoracic Aorta to Potassium Ion Channel Openers
Daniel U. Owu, Nelson N. Orie, Chukwuemeka R. Nwokocha, Lucie H. Clapp, Eme E. Osim
Journal of Advances in Medicine and Medical Research · pp. 748–759 · Published 28 Feb 2013
10.9734/BJMMR/2013/2174Abstract
Background: Diabetes mellitus is associated with many cardiovascular dysfunction and impairment of potassium channel function. Aim: We compared the vascular reactivity in aorta from streptozotocin-induced and Goto-Kakizaki (GK) diabetic rats to potassium channel openers. Methodology: Diabetes mellitus (DM) was induced in Sprague Dawley rats by intraperitoneal injection of streptozotocin (STZ) at 65 mg/kg body weight. After four weeks of DM, vascular reactivity of the aortic rings from STZ-induced Sprague Dawley and age-matched GK and control rats to phenylephrine, acetylcholine, levcromakalim and naringenin was studied using standard organ bath procedure. Results: The phenylephrine-induced contraction was significantly (P<0.05) increased in STZ-diabetic aortic rings [2.03 ±0.07 g] when compared with GK rats [1.47±0.14 g] and STZ-control [1.42±0.21 g]. Maximal relaxation and potency to acetylcholine, levcromakalim and (+/-)-naringenin were significantly (P<0.05) decreased in STZ- diabetic aorta when compared with GK-diabetic and control groups. Conclusion: The phenylephrine-induced contraction, endothelium-dependent relaxation, KATP - and (+/-)-naringenin-induced vasorelaxation are not altered in the early stages of Type 2 diabetes whereas there is exaggerated contractile response and a relaxant dysfunction involving the endothelium, KATP in Type 1 diabetes mellitus.
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Cited by 4
C. Nwokocha, Javier Palacios, V. E. Ojukwu · Archives of Physiology and Biochemistry · 2022
Sohair A. Saleh, G. Hanna, A. Gaafar · The Medical journal of Cairo University · 2018
D. Loubser · 2014
D. Owu, N. Orie, C. Nwokocha · General Physiology and Biophysics · 2013
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