Linezolid-induced Thrombocytopenia and Anaemia in a Patient with Multidrug- resistant Tuberculosis: A Case Report
J.Anantha Lakshmi, Shirisha Vodnala, Mohammed Zabeer Uddin, Sathwika vudugula, Chidurala nikitha
Asian Journal of Research in Infectious Diseases · pp. 44–50 · Published 2 May 2025
10.9734/ajrid/2025/v16i5446Abstract
Linezolid is a new class of antimicrobials with excellent safety and efficacy profiles and has been suggested as a promising alternative to treat patients with multidrug-resistant tuberculosis or extensively drug-resistant TB. While being effective in managing strains, Linezolid eventually induces haematological side effects such as severe thrombocytopenia, anaemia and leukopenia after 2 weeks of therapy. Understanding the risks of linezolid is crucial for optimising patient outcomes and minimising adverse reactions. The case of a 37-year-old female who was diagnosed with multidrug-resistant tuberculosis and was being treated with linezolid was presented. Later, the patient developed severe haematological complications as observed in laboratory investigation (haemoglobin 2.9 g/dl (12-15 g/dl), Platelet count 35 x103/mm3(150-410 x103/mm3) following cessation of linezolid, the patient’s haematological parameters gradually improved and conditions resolved.
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