Clinical Study of Neurodegenerative Treatment on Glaucoma by Insulin Intravitreal Injection
Ophthalmology Research: An International Journal · pp. 1–14 · Published 12 Oct 2022
10.9734/or/2022/v17i4368Abstract
Purpose: Our trail was to study insulin intravitreal injection’s (IIV) efficacity and safety to treat glaucoma neurodegeneration. Methods: Eleven subjects (11eyes) were recruited;10 patients treated in a double masked randomized sham controlled including 5 patients received one IIV injection 3UI and 5 patients received one injection of balanced salt solution(BSS) 3UI. A follow up during 168days was realized using Optical Coherence Tomography(OCT) and visual field(VF).The eleventh patient received two IIV injection without masking the injection content within one month between each injection and followed up for 877days.All the patients have a correct ocular pressure and no ocular treatment was stopped. Results: The 5 patients who received IIV revealed a swift improvement of decibel (DB), and remains stable during the first month. The average improvement was 6.62DB during 168days.The 5 patients treated with one BSS injection showed no significant improvement regaining 1. 45DB.The last patient who received two injections showed increase from 7.54DB to 17.22DB with a functional amelioration of 9. 68DB.The OCT examination showed a structural improvement during the first month, then returned to the initial value. No complication was observed during and after the treatment. Conclusion: Insulin shows not only efficacity and safety but more than that, the visual field(VF) of the patients became stable and show no deterioration in all the follow up, which confirmed that insulin act to improve the function rather than structure. it means insulin reconnect the stoma and improve the neurite outgrowth This treatment will change the evolution of this pathology and protect the glaucomatous patients against blindness.
References (43)
- 1 Insulin receptors are widely distributed in the central nervous system of the rat [DOI]
- 2 Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action [DOI]
- 3 Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction [DOI]
- 4 The role of insulin receptor signaling in the brain [DOI]
- 5 Cognitive impairment following high fat diet consumption is associated with brain inflammation [DOI]
- 6 Role of insulin resistance in endothelial dysfunction [DOI]
- 7 Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease [DOI]
- 8 Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. [DOI]
- 9 Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation [DOI]
- 10 Insulin signaling meets mitochondria in metabolism [DOI]
- 11 Reduced O-GlcNAcylation links lower brain glucose metabolism and tau pathology in Alzheimer's disease [DOI]
- 12 Insulin gene expression and insulin synthesis in mammalian neuronal cells. [DOI]
- 13 The Insulin Receptor Tyrosine Kinase Substrate p58/53 and the Insulin Receptor Are Components of CNS Synapses [DOI]
- 14 Neuroinflammation in Alzheimer's Disease and Parkinson's Disease: Are Microglia Pathogenic in Either Disorder? [DOI]
- 15 Amyloid-β and Mitochondria in Aging and Alzheimer's Disease: Implications for Synaptic Damage and Cognitive Decline [DOI]
- 16 Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways [DOI]
- 17 Brain glucose transporters, O‐GlcNAcylation and phosphorylation of tau in diabetes and Alzheimer’s disease [DOI]
- 18 Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management [DOI]
- 19 A new muscle glycogen storage disease associated with glycogenin-1 deficiency [DOI]
- 20 The Neurovascular Unit in Glaucomatous Neurodegeneration [DOI]
- 21 Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury [DOI]
- 22 Assessing the contribution of inflammation in models of Alzheimer's disease [DOI]
- 23 Insulin Biosynthesis, Secretion, Structure, and Structure-Activity Relationships
- 24 The Contribution of Small Vessel Disease to Neurodegeneration: Focus on Alzheimer’s Disease, Parkinson’s Disease and Multiple Sclerosis [DOI]
- 25 Akt Activation Protects Hippocampal Neurons from Apoptosis by Inhibiting Transcriptional Activity of p53 [DOI]
- 26 Quantitative autoradiographic localization of [125I]insulin‐like growth factor I, [125I]insulin‐like growth factor II, and [125I]insulin receptor binding sites in developing and adult rat brain [DOI]
- 27 Insulin as an in vivo growth factor [DOI]
- 28 Cholesterol and APOE genotype interact to influence Alzheimer disease progression [DOI]
- 29 Preproinsulin I and II mRNAs and insulin electron microscopic immunoreaction are present within the rat fetal nervous system [DOI]
- 30 Insulin inhibits amyloid β-induced cell death in cultured human brain pericytes [DOI]
- 31 Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation [DOI]
- 32 Insulin/IGF signalling in neurogenesis [DOI]
- 33 Metabolic Syndrome Is Associated With Ocular Hypertension and Glaucoma [DOI]
- 34 Insulin Signaling as a Therapeutic Target in Glaucomatous Neurodegeneration [DOI]
- 35 A New Role for SOCS in Insulin Action [DOI]
- 36 Stimulation of Immunoreactive Insulin Release by Glucose in Rat Brain Synaptosomes [DOI]
- 37 Glaucoma – Diabetes of the brain: A radical hypothesis about its nature and pathogenesis [DOI]
- 38 Release of Immunoreactive Insulin from Rat Brain Synaptosomes Under Depolarizing Conditions [DOI]
- 39 Immunocytochemistry of mouse and human retina with antisera to insulin and S-100 protein [DOI]
- 40 A Contribution to the Theory of the Vascular Origin of Glaucoma [DOI]
- 41 Phosphatidylinositol 3-kinase-mediated regulation of neuronal apoptosis and necrosis by insulin and IGF-I [DOI]
- 42 Neuronal Differentiation [DOI]
- 43 Yaşlı Kadınlarda Üreme Sağlığı
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