Chromosomal Abnormalities among Petrol Station Workers Occupationally Exposed to Benzene
N. M. El Mahdy, N. M. Radwan, H. S. Kharoub, F. El-Halawany
Current Journal of Applied Science and Technology · pp. 502–513 · Published 4 Mar 2015
10.9734/BJAST/2015/16369Abstract
It is known that the vast majority of malignancies are the result of genetic and environmental interactions. Fuel (diesel and petrol) constitutes a complex mixture of benzene, toluene and xylene and other monocyclic, aromatic, aliphatic and polycyclic aromatic hydrocarbons; benzene being the most hazardous because of its carcinogenic potency. This study aims to evaluate the genotoxic effects of occupational exposure to benzene through cytogenetic analysis at low levels of exposure also to investigate the possibility of liver and kidney affections. The studied group comprised 40 workers from 3 different petrol stations occupationally exposed to benzene and 20 control subjects. The two studied groups were matched regarding age and sex. Results show significant difference between exposed workers and control group in chromosomal abnormalities regarding mitotic index, gap, isogap and break. Regarding period of exposure, the frequency of different types of chromosomal aberrations was relatively high during first few years of exposure and decrease with increasing duration. Regarding liver function tests, levels were within normal ranges but higher in workers with statistically significant difference between exposed workers and control group and they were significantly correlated with the duration of exposure (p value= .05). Occupational exposure to mutagenic and carcinogenic agents creates a significant impact on the health status of gasoline station attendants. Identification and prevention of possible health problems related to such exposure would help in maintaining good health of workers; prevent reduction in working capacity and loss of working hours besides reducing the cost of medical care for affected workers. Further studies are needed to assess DNA status in the lymphocytes that might be a predictor of future cancer risks and might help to prevent further deterioration in the health of these workers.
References (35)
- 1 Instillation of Six Different Ultrafine Carbon Particles Indicates a Surface Area Threshold Dose for Acute Lung Inflammation in Mice [DOI]
- 2 The Toxicology of Benzene [DOI]
- 3 Genotoxicity of benzene and its metabolites [DOI]
- 4 The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene [DOI]
- 5 Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000–2001 [DOI]
- 6 Bioassay-directed fractionation and salmonella mutagenicity of automobile and forklift diesel exhaust particles. [DOI]
- 7 A Critical Evaluation of DNA Adducts as Biological Markers for Human Exposure to Polycyclic Aromatic Compounds [DOI]
- 8 Profiles of Metabolites and Gene Expression in Rats with Chemically Induced Hepatic Necrosis [DOI]
- 9 Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene [DOI]
- 10 Monitoring of gas station attendants exposure to benzene, toluene, xylene (BTX) using three-color chromosome painting [DOI]
- 11 Structure–activity relationships for halobenzene induced cytotoxicity in rat and human hepatoctyes [DOI]
- 12 Biomarkers of air pollution exposure—A study of policemen in Prague [DOI]
- 13 Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach [DOI]
- 14 Molecular Epidemiology Studies on Occupational and Environmental Exposure to Mutagens and Carcinogens, 1997-1999 [DOI]
- 15 Cytogenetic abnormalities in the myelodysplastic syndromes and occupational or environmental exposure [DOI]
- 16 Genetic effects of petroleum fuels: cytogenetic monitoring of gasoline station attendants [DOI]
- 17 Occupational genotoxicity risk evaluation through the comet assay and the micronucleus test.
- 18 Sister chromatid exchange (SCE) and micronucleus (MN) frequencies in lymphocytes of gasoline station attendants [DOI]
- 19 Lymphocyte phenotype analysis and chromosome aberration frequency of workers occupationally exposed to styrene, benzene, polycyclic aromatic hydrocarbons or mixed solvents [DOI]
- 20 Use of OctoChrome fluorescence in situ hybridization to detect specific aneuploidy among all 24 chromosomes in benzene-exposed workers [DOI]
- 21 Determination of genetic damage and urinary metabolites in fuel filling station attendants [DOI]
- 22 Evaluation of genotoxic effects of benzene and its derivatives in workers of gas stations [DOI]
- 23 Monitoring of benzene-exposed workers for genotoxic effects of benzene: improved-working-condition-related decrease in the frequencies of chromosomal aberrations in peripheral blood lymphocytes [DOI]
- 24 Analytical method for evaluation of exposure to benzene, toluene, xylene in blood by gas chromatography preceded by solid phase microextraction [DOI]
- 25 Daño hepático en trabajadores expuestos a hidrocarburos [DOI]
- 26 Benzene exposure and hypertension: an observation.
- 27 Electronic noses for monitoring benzene occupational exposure in biological samples of Egyptian workers [DOI]
- 28 Chromosome aberrations and DNA damage in petrol pump workers in Chiang Mai
- 29 Cytogenetic studies on rural populations exposed to pesticides [DOI]
- 30 Genetic effects of petroleum fuels: II. Analysis of chromosome loss and hyperploidy in peripheral lymphocytes of gasoline station attendants [DOI]
- 31 Benzo[a]pyrene-7,8-dihydrodiol Promotes Checkpoint Activation and G2/M Arrest in Human Bronchoalveolar Carcinoma H358 Cells [DOI]
- 32 Chromosomal rearrangements, genes, and fragile sites in cancer: clinical and biologic implications.
- 33 BIOLOGICAL ASSESSMENT OF EXPOSURE TO BENZENE AMONG PETROL STATIONS’ WORKERS IN ZAGAZIG CITY BY USING TRANS,TRANS-MUCONIC ACID AS URINARY INDICATOR [DOI]
- 34 Assessment of health effects [DOI]
- 35 Hepatotoxicity. The adverse effects of drugs and other chemicals on the liver [DOI]
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