Chloroquine Resistance in a Case with Uncomplicated Plasmodium vivax Malaria: An Evolving Threat
Current Journal of Applied Science and Technology · pp. 1–4 · Published 18 Nov 2015
10.9734/BJAST/2016/22553Abstract
Introduction: Chloroquine resistance is an emerging phenomenon in uncomplicated Plasmodium vivaxmalaria. Presentation of Case: This case report describes a 21 year old forest worker who was diagnosed to have Plasmodium vivax malaria on blood film microscopy and it was confirmed on molecular real-time polymerase chain reaction analysis. He was treated with conventional oral chloroquine of optimal dosage in which he failed to respond appropriately. His blood film parasite count increased on day 3 of treatment despite adequate chloroquine therapy. He was then commenced on oral artemether-lumefantrine (Riamet) combination therapy in which he responded clinically and microscopically. He was discharged from the hospital after completing a 14-day course of oral primaquine. His serial blood films were negative for more than three consecutive days whilst in hospital. On subsequent weekly follow ups at the specialist clinic for a duration of 28 days, his blood films remained negative for malaria parasites. Conclusion: Chloroquine resistance is now an emerging threat in many middle and low income countries globally.
References (8)
- 1 Plasmodium knowlesi: The Fifth Human Malaria Parasite [DOI]
- 2 Chloroquine Resistant Plasmodium vivax: In Vitro Characterisation and Association with Molecular Polymorphisms [DOI]
- 3 Increasing Incidence of Plasmodium knowlesi Malaria following Control of P. falciparum and P. vivax Malaria in Sabah, Malaysia [DOI]
- 4 Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum [DOI]
- 5 Vivax malaria and chloroquine resistance: a neglected disease as an emerging threat [DOI]
- 6 Survey of resistance to chloroquine by Plasmodium vivax in Indonesia [DOI]
- 7 Novel mutations in the antifolate drug resistance marker genes among Plasmodium vivax isolates exhibiting severe manifestations [DOI]
- 8 Malaria and deaths in the English marshes – Authors' reply [DOI]
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