Chemical Constituents from Wood of Zanthoxylum rigidum Hum. & Bonpl. Ex Willd (Rutaceae) and Antileishmanial Activity
Carlos H. C. dos Santos, Mayara C. Sousa, Paulo T. de Sousa Jr., Tereza A. N. Ribeiro, Marco J. Jacinto, Virgínia C. Paulino Silva
European Journal of Medicinal Plants · pp. 14–20 · Published 15 Jul 2021
10.9734/ejmp/2021/v32i530390Abstract
In this study was reported the structural elucidation by means of nuclear magnetic resonance (1D and 2D), FT-IR and mass spectrometry of lupeol (1), a mixture of the steroids campesterol (2), b-sitosterol (3) and stigmasterol (4), sesamin (5), trans-dimethylmatairesinol (6), trans-methylpluviatolide (7), quercetin (8), and d-mannitol (9) isolated from wood of Zanthoxylum rigidum. The lignans 5, 6 and 7 were tested for their ability to inhibit the proliferation of the promastigote forms of Leishmania braziliensis and Leishmania chagasi. Only sesamin (5) and trans-methylpluviatolide (7) showed moderate inhibitory activity with IC50 = 22.4 and 33.6, SI = 3.87 and 2.41 and CC50 = 86.9 and 81.2, for L. braziliensis and L. chagasi, respectively, compared to the positive control (amphotericin B).
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