Comparative Study of the Synthesis of 7 Hydroxy-4-Methyl Coumarin Mannich Bases by Conventional and Microwave Method
Yashumati R. Bhardwaj, Monika Chauhan, Ashutosh Pareek, Dharma Kishore
International Research Journal of Pure and Applied Chemistry · pp. 250–256 · Published 27 Jun 2013
10.9734/IRJPAC/2013/4526Abstract
Present work describes the synthesis of coumarin Mannich bases 4-7 by the application of Mannich reaction on 7-hydroxy-4-methyl coumarin 3 using conventional as well as microwave technology to compare the feasibility, reaction time and yield of the product. For this, 7-hydroxy-4-methyl coumarin 3 was prepared using Pechmann condensation reaction and Mannich bases (4-7) were synthesized by the reaction of 3 with various secondary amines. A comparison between the conventional and microwave methods demonstrated that the microwave assisted synthesis was more convenient and simpler method with better yield and lesser formation of by-products of compounds 4-7 as compared to conventional method of synthesis.
Cited by 2
Lamine Cisse, Abdoulaye Djande, Martine Capo‐Chichi · Journal of Physical Organic Chemistry · 2019
J. Sergio Durand-Niconoff, Erik Ortiz-Blanco, Gabriela Sosa-Ortiz · RSC Advances · 2021
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