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Research Article Open access CC BY 3.0

Celiac and Non-Celiac Forms of Gluten Sensitivity: Shifting Paradigms of an Old Disease

Karol Sestak, Ilana Fortgang

Microbiology Research Journal International · pp. 585–589 · Published 24 Aug 2013

10.9734/BMRJ/2013/6083

Abstract

Gluten sensitivity is one of the prominent features of celiac disease (CD) which is an autoimmune disorder characterized by damaged lining of the small intestine. CD was known already to ancient Greeks as κοιλιακÏŒς (keeleeakoss) i.e. disease of the abdominal cavity hence celiac. Focus of this Commentary article is on rather complex definition of CD and its emerging new forms the example of which is non-celiac gluten sensitivity. It is becoming evident that to formulate more effective treatments, these associations and newly identified disease entities deserve attention from both academic and clinical communities.

Celiac gluten autoimmunity tissue transglutaminase.

References (18)

  1. 1 Celiac Disease
  2. 2 Structural Basis for Gluten Intolerance in Celiac Sprue [DOI]
  3. 3 Tissue transglutaminase selectively modifies gliadin peptides that are recognized by gut-derived T cells in celiac disease [DOI]
  4. 4 Spectrum of gluten-related disorders: consensus on new nomenclature and classification [DOI]
  5. 5 Celiac Disease: From Pathogenesis to Novel Therapies [DOI]
  6. 6 Cutting Edge: Selective Deamidation by Tissue Transglutaminase Strongly Enhances Gliadin-Specific T Cell Reactivity [DOI]
  7. 7 Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity [DOI]
  8. 8 Gluten sensitivity: from gut to brain [DOI]
  9. 9 Serological Tests in Gluten Sensitivity (Nonceliac Gluten Intolerance) [DOI]
  10. 10 Celiac disease [DOI]
  11. 11 Coeliac disease and gluten sensitivity [DOI]
  12. 12 Intolerance to Cereals Is Not Specific for Coeliac Disease [DOI]
  13. 13 Gliadin Fragments Induce Phenotypic and Functional Maturation of Human Dendritic Cells [DOI]
  14. 14 Autoantibodies against epidermal transglutaminase are a sensitive diagnostic marker in patients with dermatitis herpetiformis on a normal or gluten-free diet [DOI]
  15. 15 Role of transglutaminase 2 in celiac disease pathogenesis [DOI]
  16. 16 Intestinal T-cell Responses in Celiac Disease – Impact of Celiac Disease Associated Bacteria [DOI]
  17. 17 Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease [DOI]
  18. 18 Does gluten sensitivity in the absence of coeliac disease exist? [DOI]

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