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Research Article Open access CC BY 4.0

Cardiac Dysfunction in Patients with Sepsis, Severe Sepsis and Septic Shock

Tom Devasia, Hashir Kareem, Y. G. Ashok Kumar, R. Padma Kumar, Saumya Jose, Sharmila Sadanand Prabhu, Umesh Pai, Krishnanand Nayak, Tulsee Sitapara, Ashok Thakkar

Journal of Advances in Medicine and Medical Research · pp. 427–433 · Published 16 Sep 2014

10.9734/BJMMR/2015/12334

Abstract

Aims: Patients with severe sepsis and septic shock often exhibit significant cardiovascular dysfunction. We designed the study with an aim to determine the severity of cardiac dysfunction in the different group of sepsis patients. Study Design: Single-center, cross-sectional study Place and Duration of Study: The study was carried out at Department of Cardiology, Kasturba Medical College and Hospital, Manipal from June 2011 to December 2012. Methodology: A total of 74 patients who were diagnosed with sepsis were enrolled in the study. All patients were subjected to routine analysis, laboratory test and echocardiogrphic assessment. Results: The patients were divided into 3 groups: sepsis group (n = 11), severe sepsis group (n = 37) and septic shock group (n = 26). The mitral E/A value is significantly higher in patients with septic shock than that of the patients with sepsis (P = 0.04). The indices of right ventricular dysfunction did not show any significant difference in the patients with septic shock and that of sepsis. Conclusion: Left ventricular dysfunction may be considered prevalent in sepsis as per the significant E/A values. However, the other echocardiographic parameter should also be considered. This may even infer that cardiac dysfunction may not correlate with the severity of sepsis.

Cardiac dysfunction septic shock sepsis severe sepsis echocardiography

References (33)

  1. 1 Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis [DOI]
  2. 2 Critical Care Medicine [DOI]
  3. 3 Profound but Reversible Myocardial Depression in Patients with Septic Shock [DOI]
  4. 4 Pathogenetic Mechanisms of Septic Shock [DOI]
  5. 5 Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: A trend analysis from 1993 to 2003* [DOI]
  6. 6 Septic shock [DOI]
  7. 7 Noninvasive Doppler-derived myocardial performance index: Correlation with simultaneous measurements of cardiac catheterization measurements [DOI]
  8. 8 New non-invasive index for combined systolic and diastolic ventricular function.
  9. 9 Diastolic dysfunction and mortality in severe sepsis and septic shock [DOI]
  10. 10 Clinical review: Myocardial depression in sepsis and septic shock. [DOI]
  11. 11 Right Ventricular Dysfunction and Dilatation, Similar to Left Ventricular Changes, Characterize the Cardiac Depression of Septic Shock in Humans [DOI]
  12. 12 Statin Treatment After Onset of Sepsis in a Murine Model Improves Survival [DOI]
  13. 13 HMG-CoA Reductase Inhibitor Simvastatin Profoundly Improves Survival in a Murine Model of Sepsis [DOI]
  14. 14 Left ventricular systolic and diastolic function in septic shock [DOI]
  15. 15 Persistent Preload Defect in Severe Sepsis Despite Fluid Loading [DOI]
  16. 16 MYOCARDIAL DYSFUNCTION IN SEPTIC SHOCK [DOI]
  17. 17 Epidemiology of cardiovascular disease in the 21st century: Updated updated numbers and updated facts
  18. 18 Occurrence and outcomes of sepsis: Influence of race* [DOI]
  19. 19 Diastolic dysfunction and mortality in early severe sepsis and septic shock: a prospective, observational echocardiography study [DOI]
  20. 20 Hemodynamic Instability in Sepsis [DOI]
  21. 21 Left ventricular diastolic function in sepsis [DOI]
  22. 22 Diastolic filling in human severe sepsis [DOI]
  23. 23 Assessing left ventricular systolic function in shock: evaluation of echocardiographic parameters in intensive care [DOI]
  24. 24 Myocardial Dysfunction in Severe Sepsis and Septic Shock: More Questions Than Answers? [DOI]
  25. 25 Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis* [DOI]
  26. 26 Toll-like receptor 3 plays a central role in cardiac dysfunction during polymicrobial sepsis* [DOI]
  27. 27 Sepsis-Induced Depressed Contractile Function of Isolated Ventricular Myocytes Is Due to Altered Calcium Transient Properties [DOI]
  28. 28 Assessment of right ventricular functions in patients with sepsis, severe sepsis and septic shock and its prognostic importance: A tissue Doppler study [DOI]
  29. 29 Pathomechanisms of Myocardial Dysfunction in Sepsis [DOI]
  30. 30 Sepsis-induced diastolic dysfunction in chronic canine peritonitis [DOI]
  31. 31 Cardiac functions in patients with sepsis and septic shock [DOI]
  32. 32 The American Journal of Respiratory and Critical Care Medicine
  33. 33 Coronary Heart Disease Risk Factors and Mortality [DOI]

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