Antiproliferative Activity of Ethanol Extract of Boswellia dalzielii (Hutch) Stem Bark in Breast Cancer Cell Line
A. P. Otitoju, I. Y. Longdet, T. E. Alemika, V. P. Gota
Journal of Complementary and Alternative Medical Research · pp. 11–16 · Published 20 Oct 2020
10.9734/jocamr/2020/v11i230180Abstract
Aim and Objectives: The present study aimed to examine the antiproliferative activity of ethanol extract derived from the Boswellia dalzielii stem bark in breast carcinoma. Methodology: Ethanolic extract of stem bark of Boswellia dalzielii were prepared. Antiproliferative activity was assessed in estrogen receptor (ER)-negative breast carcinoma (MDA-MB-231) cells by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay. Results: Obtained results in 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay indicated that ethanol extract of Boswellia dalzielii stem bark showed significant antiproliferative activity in MDA-MB-231 cells in a dose-dependent manner. IC50 of Boswellia dalzielii stem bark ethanol extract in MDA-MB231 was 98. 12 μg/mL. Conclusion: The results obtained suggest that Boswellia dalzielii stem bark extract possesses significant antiproliferative potential which could be mediated by the chemical constituents present in the plant. However, further research needs to be carried out to determine the effect of the extract on the cell cycle and also to determine the type of cell death produced by the extract.
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