Biological and Biochemical Efficiency of Lyophilized Cranberry Extract on Regulation of Antioxidant Defense System in Nonalcoholic Steatohepatitic Rats
Annual Research & Review in Biology · pp. 4137–4151 · Published 29 Jul 2014
10.9734/ARRB/2014/6492Abstract
Cranberries are small, dark red fruits that are widely consumed as juice. Nonalcoholic steatohepatitis (NASH) is a condition that may progress to end-stage liver disease. Rats were classified into four groups as follows: normal control group, NASH rats fed high fat diet, nonalcoholic steatohepatitic rats fed high fat diet and received lyophilized powdered cranberry suspended in 0.5% CMC, group fed basal diet and received lyophilized powdered cranberry suspended in 0.5% carboxymethyl cellulose CMC. The model of NASH rats elicited significant increase in serum lipid parameters: total cholesterol, total lipids, tricylglycerols and phospholipids, liver antioxidant enzyme activities with concomitant significant elevations in liver enzymes and glucose-6-phosphate dehydrogenase, in association with a reduction in reduced glutathione, glutathione peroxidase, serum total protein and direct and total bilirubin. Administration of cranberry to NASH rats produced significant increases in tested antioxidant enzyme activities, G6PD and serum total protein, direct and total bilirubin concomitant with significant decreases in the levels of serum lipids as well as liver enzymes AST, ALT, ALP, GST and ɣ-GT. In addition, it was noted that NASH rats exhibited a degree of DNA fragmentation; however, oral administration of cranberry extract partially inhibited the DNA fragmentation.
References (58)
- 1 Tissue sulfhydryl groups [DOI]
- 2 Glutathione S-Transferases [DOI]
- 3 Design and validation of a histological scoring system for nonalcoholic fatty liver disease† [DOI]
- 4 Enzymatic Determination of Total Serum Cholesterol [DOI]
- 5 How mitochondria produce reactive oxygen species [DOI]
- 6 Mitochondrial formation of reactive oxygen species [DOI]
- 7 Adipose tissue dysfunction in obesity, diabetes, and vascular diseases [DOI]
- 8 Prevalence of and Risk Factors for Nonalcoholic Fatty Liver Disease: The Dionysos Nutrition and Liver Study * # [DOI]
- 9 Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ [DOI]
- 10 The sites and topology of mitochondrial superoxide production [DOI]
- 11 A new enzymatic method for determination of serum choline-containing phospholipids [DOI]
- 12 Reactive oxygen species, cell signaling, and cell injury [DOI]
- 13 Mitochondrial dysfunction in NASH: Causes, consequences and possible means to prevent it [DOI]
- 14 Anthocyanins and other flavonoids [DOI]
- 15 Scavenging Capacity of Berry Crops on Superoxide Radicals, Hydrogen Peroxide, Hydroxyl Radicals, and Singlet Oxygen [DOI]
- 16 Nutrition and health aspects of free radicals and antioxidants [DOI]
- 17 Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis [DOI]
- 18 A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity [DOI]
- 19 In situ detection of lipid peroxidation and oxidative DNA damage in non-alcoholic fatty liver diseases [DOI]
- 20 Energetics, epigenetics, mitochondrial genetics [DOI]
- 21 A-Type Proanthocyanidin Trimers from Cranberry that Inhibit Adherence of Uropathogenic P-Fimbriated Escherichia c oli [DOI]
- 22 Anti-angiogenic, Antioxidant, and Anti-carcinogenic Properties of a Novel Anthocyanin-Rich Berry Extract Formula [DOI]
- 23 Antioxidant activity and antimicrobial effect of berry phenolics – a Finnish perspective [DOI]
- 24 Analytical methods for assay of ellagic acid and its solubility studies [DOI]
- 25 Specific Contribution of Methionine and Choline in Nutritional Nonalcoholic Steatohepatitis [DOI]
- 26 Cranberries (Vaccinium macrocarpon) and Cardiovascular Disease Risk Factors [DOI]
- 27 Mitochondrial glutathione: Hepatocellular survival–death switch [DOI]
- 28 Cranberry (Vaccinium macrocarpon) protects against doxorubicin-induced cardiotoxicity in rats [DOI]
- 29 Polyphenolic Composition and Antioxidant Capacity of Extruded Cranberry Pomace [DOI]
- 30 Phytochemical accumulation and antioxidant capacity at four maturity stages of cranberry fruit [DOI]
- 31 Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men [DOI]
- 32 Mitochondrial involvement in non-alcoholic steatohepatitis [DOI]
- 33 Comparative effects of flavonoids on oxidant scavenging and ischemia-reperfusion injury in cardiomyocytes [DOI]
- 34 Cranberries inhibit LDL oxidation and induce LDL receptor expression in hepatocytes [DOI]
- 35 In vitro binding of bile acids by blueberries (Vaccinium spp.), plums (Prunus spp.), prunes (Prunus spp.), strawberries (Fragaria X ananassa), cherries (Malpighia punicifolia), cranberries (Vaccinium macrocarpon) and apples (Malus sylvestris) [DOI]
- 36 Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia–reperfusion injury [DOI]
- 37 Effect of green tea extracts on liver functions in Wistar rats [DOI]
- 38 Improved micro-method for determination of serum bilirubin [DOI]
- 39 Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides [DOI]
- 40 In Vivo Antioxidant Activity of Procyanidin-Rich Extracts from Grape Seed and Pine (Pinus Maritima) Bark in Rats [DOI]
- 41 Impact of Berry Phytochemicals on Human Health: Effects beyond Antioxidation [DOI]
- 42 Antioxidant defence mechanisms: new players in the pathogenesis of non-alcoholic steatohepatitis? [DOI]
- 43 Effects of dietary consumption of cranberry powder on metabolic parameters in growing rats fed high fructose diets [DOI]
- 44 Cranberry Juice Increases Antioxidant Status Without Affecting Cholesterol Homeostasis in Orchidectomized Rats [DOI]
- 45 Decreased ANT content in Zucker fatty rats: Relevance for altered hepatic mitochondrial bioenergetics in steatosis [DOI]
- 46 Pro-oxidant effect of dehydroepiandrosterone in rats is mediated by PPAR activation [DOI]
- 47 Cranberry phenolics-mediated antioxidant enzyme response in oxidatively stressed porcine muscle [DOI]
- 48 Post-translational Regulation of Glucose-6-phosphate Dehydrogenase Activity in (Pre)neoplastic Lesions in Rat Liver [DOI]
- 49 Cranberry and Strawberry Juices - Influence of Method Production on Antioxidants Content And Antioxidative Capacity [DOI]
- 50 FORTIFICATION OF ATHEROGENIC DIET WITH CRANBERRY EXTRACT AND SPINACH: PLASMA LDL OXIDATION AND OTHER ATHEROSCLEROSIS RISK FACTORS IN RATS [DOI]
- 51 Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple [DOI]
- 52 Steatohepatitis: A tale of two “hits”? [DOI]
- 53 Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. [DOI]
- 54 Nonalcoholic Steatohepatitis: Summary of An Aasld Single Topic Conference [DOI]
- 55 High Alanine Aminotransferase Is Associated With Decreased Hepatic Insulin Sensitivity and Predicts the Development of Type 2 Diabetes [DOI]
- 56 Contribution of adipose tissue and de novo lipogenesis to nonalcoholic fatty liver disease [DOI]
- 57 Superoxide dismutase and glutathione peroxidase activities in neutrophils from selenium deficient and copper deficient cattle [DOI]
- 58 Pomegranate Fruit Extract Modulates UV-B–mediated Phosphorylation of Mitogen-activated Protein Kinases and Activation of Nuclear Factor Kappa B in Normal Human Epidermal Keratinocytes¶ [DOI]
Cited by 0
No indexed citations yet.
Related research
- Salivary Lipid Peroxidation and Antioxidant Status in Nigerian Cigarette Smokers with or Without Periodontitis — shares topic coverage
- Effects of Restraint Stress and Cadmium Chloride on the Liver Function of Female Wistar Rats (Rattus norvegicus) — shares topic coverage
- Oxidative Stress Biomarkers (Malondialdehyde, Superoxide Dismutase, and Catalase) as Predictors of Cardiovascular Disease Risk: A Review — shares topic coverage
- Comparative Effects of Light and Water Stresses on Antioxidant Enzymes Activity of Three Ecotypes of Jatropha curcas Seedlings — shares topic coverage
- Antioxidant Enzymes and Germination Pattern: Upshot of High Salinity on Soluble Protein and Average Weight of Spinacia oleracea (Spinach) Seedlings — shares topic coverage
Article metrics
Real usage data collected on this platform.
10
Page views
0
PDF downloads
0
Outbound clicks
0
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.