Vitamins C and E Alleviate Nephrotoxicity-induced by Potassium Bromate in Rats

Abstract

Potassium bromate (KBrO3) is widely used in foods and water, in spite of its well-known oxidative cell and tissue damage. Therefore; vitamins C (vit C) and E (vit E) are examined to alleviate its nephrotoxicity. For this purpose 72 adult male albino rats were categorized into 6 groups. Group1 served as control; group 2 served 30 mg/Kg/ day vit C; group 3 served 300 mg/kg/day vit E; group 4 was injected intraperitoneally with KBrO3 20 mg/Kg/ dose twice weekly; and groups 5 and 6 received either vit C or E with KBrO3 in the same scheme. After 4 weeks, kidney and serum were collected for analysis. KBrO3-induced nephrotoxicity was evidenced by a significant increase in serum urea, creatinine and uric acid levels. Significant elevation in kidney injury molecule-1, interleukin-6, malondialdehyde levels and xanthine oxidase activity and a decrease in superoxide dismutase activity were noticed in KBrO3-intoxicated rats. These changes were ameliorated in the vit C and E-treated groups through their antioxidant and anti-inflammatory properties.