Synthesis of Novel 1,2,4-triazole-DTC Based Metallo-phosphorous Nanoformulations as Larvicide against Aedes aegypti

Abstract

Aims: The present study involved the synthesis of heteroleptic metal complexes and their nanoformulations as potential larvicidal agent. Study Design: Metal complexes nanoformulations. Place and Duration of Study: Department of Chemistry, Punjab agricultural University, Ludhiana, Punjab, India between January 2016 and February 2017. Methodology: Heteroleptic metal complexes of  Cu(II), Co(II) and Fe(III), using 1,2,4-triazole-dithiocarbamate, isothiocyanate and triphenyl phosphine ligands were prepared and converted to water dispersible nano-formulations using PVP (Polyvinyl pyrollidine) as capping as well as stabilizing agent and sodium dodecyl sulfate (SDS) as surfactant. The structures of metal complexes and their nanoformulations were characterized on the basis of elemental analysis, spectral techniques, and TEM analysis. The anti-larval evaluation of the nano-formulations against Aedes aegypti was made on the basis by the standard guidelines of World Health Organization (2005). Results: The anti-larval evaluation of the nano-formulations against Aedes aegypti revealed that the formulations were found to be highly active against the test specie at concentrations as low as 10 ppm, with copper analogues being the most active among series. Conclusion: The less toxic behaviour of these metal complexes as aqua nano formulations endorsed their use in place of earlier used phospho-analogues.