Association of Genetic Polymorphism of Tumor Necrosis Factor-α in the Development of Coronary Heart Disease in Elderly Patients
Bekkhan Saidmagomedovich Mezhidov, Khava Idrisovna Bekova, Aishat Alikovna Edieva, Khava Ismailovna Madalova, Victoria Alekseevna Malakhova, Zama Arbievna Uspaeva, Markha Sharipovna Tachaeva, Amina Magomedovna Tsinaeva, Alina Yurievna Maslova, Shamil Vakhaevich Khodisov
Journal of Pharmaceutical Research International · pp. 81–88 · Published 11 Dec 2021
10.9734/jpri/2021/v33i54B33768Abstract
The research project outlines a new look at the concept of "inflammaging" and the role of the subclinical inflammatory process in various age-associated pathology, in particular coronary heart disease. Particular attention is paid to the tumor necrosis factor-α -cytokine, which plays an important role in the pathogenesis of chronic inflammatory processes and in the aging process. The increased content of tumor necrosis factor-α leads to the emergence and accumulation of various diseases, disability and mortality of elderly and senile people. Tumor necrosis factor-α influences various risk factors for cardiovascular pathology. This substance aggravates various breakdowns in metabolism, primarily causing insulin resistance. Tumor necrosis factor-α is a key cytokine that stimulates bone resorption (osteoporosis) and sarcopenia. Currently available data prove the important role of tumor necrosis factor-α in various age-associated pathologies.
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