Association of Angiotensin-I-Converting Enzyme (ACE) Insertion/Deletion Gene Polymorphism with End Stage Renal Disease in Egyptian Patients

Abstract

Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to end stage renal disease (ESRD) in different populations. ACE DD genotype and D allele are associated with ESRD as risk factors in several studies. In this study, we investigated the association between ACE I/D gene polymorphism and ESRD in the Egyptian patients. Frequencies of D allele and DD genotype were significantly increased, while frequencies of I allele and ID genotype were significantly decreased in the ESRD patients when compared with the control subjects (P = .012, OR = 1.82, 95% CI = 1.139-2.915 for DD) and (P = .018, OR = 1.6, 95% CI = 1.082-2.33 for D). In conclusion, ACE DD genotype and D allele are associated with ESRD as risk factors for ESRD in the Egyptian population.