Assessment of the Dermal Acute Irritation Potential of Natural Veterinary Medicine Minyak Rajas in Albino Rabbits

Abstract

Aims: This study was designed to assess the potential for acute dermal irritation of natural veterinary medicine Minyak Rajas (produce by Songgolangit Persada Limited Company, Bali, Indonesia) in albino rabbits. It is a rather thick liquid which contains various medicinal herbal extracts, formulated with effective microorganism technology. This medicine is effective in the treatment of skin infections and inflammation, wounds, intestinal worms and digestive disorder. Additionally, it works for game fowl muscle strengthening. Place and Duration of Study: This study was conducted at the Veterinary Pharmacy and Pharmacology Laboratory, Faculty of Veterinary Medicine, Udayana University, between April 2020 and May 2020. Methodology: Experimental animals used were three male albino rabbits (Oryctolagus cuniculus) in healthy conditions and weighing of >2 Kg. Test procedures followed the guidelines of Organisation for Economic Cooperation and Development, and chemicals used were applied in a single dose of 0.5 ml on animal skins, with untreated skin as a control. Results: Very slight erythema was found after the Minyak Rajas application and the lesion was about 48 hours. Overall, no severe erythema, edema or other skin lesions were observed. According to the Amanded Draize system, the Primary Irritation Indexes of 0.16 is categorized as non-irritating. Conclusion: We conclude that the natural veterinary medicine of Minyak Rajasis safe to be used.