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Research Article Open access CC BY 4.0

Assessment of Parkia biglobosa on Hepatic and Renal Biomarkers of Dexamethasone-Exposed Pregnant Rats

Funmilola Comfort Oladele, Gbenga David Olubunmi, Ruth Odu Odeh, Augustine Ikhueoya Airaodion

Annual Research & Review in Biology · pp. 138–145 · Published 23 Dec 2021

10.9734/arrb/2021/v36i1230471

Abstract

Aim: This study sought to investigate its effect on hepatic and renal biomarkers of female pregnant rats. Place and Duration: This work was carried out in the Department of Medical Biochemistry and Department of Science Laboratory Technology, Ekiti State University, Ado Ekiti between January and June 2021. Methodology: Locust bean seeds were purchased from an open market in Ado Ekiti, Nigeria and were processed using standard method. Fifteen female pregnant rats were divided into three groups of five each. Animals in group A were exposed to standard animal feed only. This served as the control group. Those in group B were exposed to animal feed mixed with locust beans + 0.3 mg/kg body weight of dexamethasone, while those in group C were exposed to animal feed mixed with locust beans only. At the end of the eight days treatment, animals were sacrificed and blood sample, liver and kidney were collected. Results: Exposure of pregnant rats to dexamethasone was observed to significantly (p<0.05) increased the activities of plasma aspartate amino transaminase (AST) and alanine amino transferase (ALT) as well as the concentrations of plasma total protein, bilirubin, creatinine and urea when compared with those in animals in the control as well as those treated with P. biglobosa only. The results further showed that administration of P. biglobosa only had no significant effect on plasma hepatic and renal biomarkers except urea which was significantly lower than those in the control group as well as those treated with dexamethasone. The results obtained from liver and kidney homogenate respectively are similar to those observed in the plasma. Conclusion: Exposure of animals to dexamethasone adversely unhinged hepatic and renal biomarkers investigated in the study. The study also revealed that P. biglobosa seed is beneficial to the health of the liver and kidney of pregnant female rats.

Dexamethasone Pregnancy Parkia biglobosa Liver Kidney

References (26)

  1. 1 Renal Vulnerability to Drug Toxicity [DOI]
  2. 2 Bilirubin toxicity in the developing nervous system [DOI]
  3. 3 Comparison of Kidney Injury Molecule-1 and Other Nephrotoxicity Biomarkers in Urine and Kidney Following Acute Exposure to Gentamicin, Mercury, and Chromium [DOI]
  4. 4 Is Liver Enzyme Release Really Associated with Cell Necrosis Induced by Oxidant Stress? [DOI]
  5. 5 Serum Total Bilirubin Level, Prevalent Stroke, and Stroke Outcomes: NHANES 1999–2004 [DOI]
  6. 6 POSSIBLE ANTIDIABETIC AND ANTIHYPERLIPIDAEMIC EFFECT OF FERMENTED PARKIA BIGLOBOSA (JACQ) EXTRACT IN ALLOXAN‐INDUCED DIABETIC RATS§ [DOI]
  7. 7 A New Diazo Method for the Determination of Bilirubin [DOI]
  8. 8 Persistent organic pollutants and liver dysfunction biomarkers in a population-based human sample of men and women [DOI]
  9. 9 ESTIMATION OF BLOOD UREA (BUN) AND SERUM CREATININE LEVEL IN PATIENTS OF RENAL DISORDER
  10. 10 Alteration in biochemical indices following chronic administration of methanolic extract of Nigeria bee propolis in Wistar rats [DOI]
  11. 11 Safety Evaluation of Giant African Land Snails (Archachatina maginata) Haemolymph on Hematological and Biochemical Parameters of Albino Rats [DOI]
  12. 12 Effect of Oral Intake of African Locust Bean on Fasting Blood Sugar and Lipid Profile of Albino Rats [DOI]
  13. 13 Hepatoprotective Potency of Ethanolic Extract of Garcinia kola (Heckel) Seed against Acute Ethanol-induced Oxidative Stress in Wistar Rats
  14. 14 Nephrotoxicity of Monosodium Glutamate (MSG) in Wistar Rats
  15. 15 Effect of Cyperus esculentus L. (Tiger Nut) Milk on Hepatic and Renal Indices of Wistar Rat
  16. 16 Mechanisms of cellular enzyme release. I. Alteration in membrane fluidity and permeability. [DOI]
  17. 17 Biochemical Changes Associated with Consumption (by Rats) of “Garri” Processed by Traditional and Instant Mechanical Methods [DOI]
  18. 18 Nephro- and Hepato-TOXICITY of Common Household Insecticides Used in Nigeria
  19. 19 Bioactive Compounds of the Stem Bark of Parkia Biglobosa [DOI]
  20. 20 Nephro and Hepatotoxic Effect of Air-Freshener in Wistar Rats
  21. 21 Nephrotoxicity of Ethanol Extract of Xylopia aethiopica Fruit in Wistar Rats
  22. 22 Effect of Bambara Nut on Hepatic Biomarkers of Wistar Rats
  23. 23 Indian Journal of Experimental Biology [DOI]
  24. 24 The first known larva of the Australian tribe Mystropomini (Coleoptera: Carabidae: Paussinae) [DOI]
  25. 25 International Journal of Bio-Science and Bio-Technology [DOI]
  26. 26 Asian Journal of Biochemistry, Genetics and Molecular Biology [DOI]

Cited by 1

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