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Research Article Open access CC BY 4.0

Assessment of Insulin Resistance among Obese People at Shendi Locality, Sudan

Tibyan Abdalmajed Altaher, Mosab Omer Khalid, Ghanem Mohammed Mahjaf, Babbiker Mohammed Taher Gorish, Haghamad Allzain

Asian Journal of Research in Biochemistry · pp. 39–44 · Published 23 Dec 2022

10.9734/ajrb/2022/v11i2215

Abstract

Insulin resistance (IR) is an essential factor in the etiology of type2 diabetes and is likewise related to a big range of different pathophysiologic sequelae along with hypertension, hyperlipidemia. we carried out this cross-sectional examination to the evaluation of insulin resistance in obese people. A total of 60 obese people 20% males and 80% female were divided into 4 groups overweight (20.0%), obesity class1(36.6%), obesity class2(16.6%), and obesity class3(26.6%). Blood samples were obtained from each participant and analyzed for fasting blood glucose (FBG) as well as insulin levels. Data were analyzed by using SPSS version 20. The results showed a positive correlation between insulin resistance and insulin levels (mean 1.1+0.91, 7.1+10.1, r=0.490, P. value= 0.0001 respectively). There was no correlation between insulin resistance and FBG (mean 1.1+0.91, 75.7+10.9, r=0.52, P. value = 0.691 respectively). The analysis also showed a significant positive correlation between insulin resistance and Waist-to-hip Ratio (WHR) (mean 1.1+0.91,0.92+.14, r=0.287, P. value =0.026 respectively). Additionally, there was no correlation between insulin resistance and BMI (mean 1.1+.91,36.6+9.92, r= 0.122, P. value =0.351 respectively). There was no correlation between insulin resistance and age (mean 1.1+.91, 30 +8.68, r=-0.154, P. value = 0.30 respectively). The analysis also showed a significant between insulin resistance and gender, males (mean 0.85+1.26) and females (mean 1.1+.91,0.64+0.97) which P. value=0.031. We conclude that insulin resistance in obesity has a positive correlation with fasting insulin levels and waist-to-hip ratio. Insulin resistance was more prevalent in males more than in females.

Insulin resistance obesity C-peptide β-cell body mass index

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