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Research Article Open access CC BY 4.0

Assessment of Anti-atopic Dermatitis Activity of Oroxylum indicum Extract Incorporated Cream

Do Hoang Thu Trang, Hoang Le Son

Journal of Pharmaceutical Research International · pp. 1–11 · Published 19 Jul 2017

10.9734/JPRI/2017/34325

Abstract

Aims: The search for plant-based treatments against atopic dermatitis (AD), a relapsing dermatological condition with high prevalence in tropical regions, has always been attracting special attention. Among many folk remedies for AD, Oroxylum indicum Linn (Bignoniaceae) is a commonly used medicinal plant whose effectiveness has not yet been scientifically reported. This study thus aimed to investigate the anti-AD activity of ethyl acetate extract from the bark of Oroxylum indicum. Methodology: Five cream formulations containing Oroxylum indicum ethyl acetate bark extract in different concentrations (0%, 1.25%, 2.5%, 3.75%, and 5%) were topically applied onto the dorsal skin of 2,4-dinitrochlorobenzene-sensitized BALB/C mice once a day during 6 weeks. Phosphate-Buffered Saline (PBS) and Protopic (Tacrolimus 0.1%) were used as negative and positive control, respectively. All mice were subjected to the assessment of AD-like symptoms including the development of eczematous skin lesions, intensity of pruritus and histological alterations. Results: The plant extract at 5% was significantly effective in suppressing the dermatitis scores by 23.26% (n=6, p<0.001) and scratching frequency by 34.86% (n=6, p<0.001) compared to the negative control while markedly reducing the signs of parakeratosis, hyperplasia, spongiosis, acanthosis, as well as the epidermal and dermal thickness in immunized mice. Conclusion: These results confirmed the inhibitory effect of Oroxylum indicum on the advance of AD at 5% when incorporated into a cream formulation and revealed the plant’s therapeutic potential in the approach to disease treatment. However, more studies on the immunosuppressive mechanism of the extract and the interplaying roles of main phytocomponents should ultimately support the utilization of this valuable medicinal plant.

2,4-dinitrochlorobenzene Oroxylum indicum bark extract dermatitis score scratching behavior histological alterations medicinal plant.

References (22)

  1. 1 Atopic Dermatitis
  2. 2 Atopic dermatitis: a disease of altered skin barrier and immune dysregulation [DOI]
  3. 3 Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice [DOI]
  4. 4 Immune mechanisms leading to atopic dermatitis [DOI]
  5. 5 Behavioral differentiation between itch and pain in mouse [DOI]
  6. 6 Glucocorticoid therapy‐induced skin atrophy [DOI]
  7. 7 Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization [DOI]
  8. 8 Epidemiology of atopic dermatitis: a review [DOI]
  9. 9 Immune Pathways in Atopic Dermatitis, and Definition of Biomarkers through Broad and Targeted Therapeutics [DOI]
  10. 10 Consensus guidelines for the management of atopic dermatitis: An A sia– P acific perspective [DOI]
  11. 11 Complementary therapy for atopic dermatitis and other allergic skin diseases: facts and controversies [DOI]
  12. 12 Separation of Flavonoids from the Leaves of Oroxylum indicum by HSCCC [DOI]
  13. 13 Atopic Dermatitis: Update and Proposed Management Algorithm [DOI]
  14. 14 Current management of atopic dermatitis and interruption of the atopic march [DOI]
  15. 15 Differential effects of Oroxylum indicum bark extracts: antioxidant, antimicrobial, cytotoxic and apoptotic study [DOI]
  16. 16 Atopic dermatitis: Review of immunopathogenesis and advances in immunosuppressive therapy [DOI]
  17. 17 Prevalence survey of dermatological conditions in mountainous north India [DOI]
  18. 18 Antiulcer Activity of the Root Bark ofOroxylum indicum. Against Experimental Gastric Ulcers [DOI]
  19. 19 Formulation and Evaluation of Herbal Fairness Cream Comprising Hydroalcoholic Extracts of Pleurotus ostreatus, Glycyrrhiza glabra and Camellia sinensis [DOI]
  20. 20 ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF ROOT BARK OF OROXYLUM INDICUM, VENT. [DOI]
  21. 21 Dwarfism Following Long-term Topical Corticosteroid Therapy [DOI]
  22. 22 Cushing's Syndrome After Topical Application of Corticosteroids [DOI]

Cited by 4

Ameliorative Efficacy of Combined Betel and Tea Tree Essential Oil-Incorporated Cream on DNCB-Induced Atopic Dermatitis-like Symptoms in BALB/c Mice

Hoang Le Son, Nguyen Huynh Mai Nhi · Asian Journal of Research in Biochemistry · 2023

Oroxylum indicum Vent.: A Review on its Phytochemical and Pharmacological Profile

K.G. SHARMA, T.L. DEVI, O.M. SINGH · Asian Journal of Chemistry · 2022

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