Antioxidant, Antibacterial, and Phytochemical Screening of Ethanolic Crude Extracts of Libyan Peganum harmala Seeds
Abdulmutalib Alabeed Allaq, Norrizah Jaafar Sidik, Aziyah Abdul-Aziz, Idris Adewale Ahmed
Journal of Pharmaceutical Research International · pp. 74–82 · Published 19 Mar 2021
10.9734/jpri/2021/v33i1331268Abstract
Peganum harmala is one of the most famous medicinal plants and natural products commonly used in traditional medicine and extensively spread in Middle and East Asia and North Africa. This study aimed to evaluate the radical scavenging activity of ethanolic crude extracts of P. harmala seeds from Libya using DPPH assay; to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) of the P. harmala seeds crude extracts against Gram-negative Salmonella typhi ATCC14028 and Escherichia coli ATCC 25922 and also Gram-positive Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 33591; and to screen the phytochemicals in the ethanolic crude extracts of the Libyan P. harmala seeds using gas chromatography-mass spectrometry (GC-MS). The IC50 value of P. harmala seeds extract was 179.62±7.32 μg/mL. The MIC ranged from 1.95 to 31.25 mg/mL while the MBC ranged from 7.80 to 62.50 mg/mL. The eight compounds identified were harmine, harmaline, leptalorine, hexahydro fluorene, 3-methoxy-6-methyl, 1H-pyrido [3,4-b]indole,2,34,9- tetrahydro-6methoxy-1-methyl, 9,12-octadienoic acid ethyl ester, linoleic acid ethyl ester, 9,12-octadienoic acid (z,z). This study has, therefore, revealed the antixodant and antibacterial efficacy of P. harmala ethanolic extract. Thus, it could be further developed as a substitute for chemical antioxidants and as antibacterials agent.
Cited by 12
Alireza Bagher Abiri, Homa Baghaei, Nurul Huda · Food Science & Nutrition · 2026
Muhanad Abdullah Abdulsamad, Nahed R. Saad, Maroua Abderrahmane Salhi · International Journal of Advancement in Life Sciences Research · 2024
Hana M. Kamoka, Asita Elengoe · Rafidain Journal of Science · 2023
Abdulmutalib Alabeed Allaq, Norrizah Jaafar Sidik, Aziyah Abdul-Aziz · Journal of Asian Scientific Research · 2022
Didem Verep Koç, Aytaç Güder, Kerim Güney · Karadeniz Fen Bilimleri Dergisi · 2024
Norhisam Zamakshshari, Idris A. Ahmed, Muhammad N.A. Nasharuddin · Journal of Applied Research on Medicinal and Aromatic Plants · 2021
Swe SL, YT Liau, YJ Wong · Research Journal of Pharmacy and Technology · 2022
Jyoti Jatav, Ayon Tarafdar, Chakkaravarthi Saravanan · Journal of Food Quality · 2022
Laboratory of Characterization and Valorization of Natural Products, Faculty of Nature and Life Sciences, University El-Bachir El-Ibrahimi, Bord jBou Arreridj, Dehiri Mounira · Biotechnologia Acta · 2022
Alireza Bagher Abiri, Homa Baghaei, Abdorreza Mohammadi Nafchi · Polymers · 2023
Related research
- Evaluation of Phytochemical Constituents and Antimicrobial Activity of Leaves and Stem Bark Extracts of Sarcocephalus latifolius — shares topic coverage
- An in-vitro Analysis of the Antioxidant and Antimicrobial Properties of the Methanol Extract of Hypoxis hemerocallideacorm (MEHHC) from Botswana — shares topic coverage
- Antimicrobial Activity of Emilia pratermissa Leaf Extracts on Organisms Isolated from Patients with Otitis Media Attending Federal Medical Centre Owo and Ondo States Specialist Hospital Akure — shares topic coverage
- Antimicrobial and Antioxidant Properties of Aqueous Garlic (Allium sativum) Extract against Staphylococcus aureus and Pseudomonas aeruginosa — shares topic coverage
- Antimicrobial Activity of Moringa oleifera Leaf against Isolates of Beef Offal — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
12
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.