Antioxidant and Anti-malarial Properties of Catechins
Iwan Budiman, Rita Tjokropranoto, Wahyu Widowati, Fanny Rahardja, Maesaroh Maesaroh, Nurul Fauziah
Journal of Advances in Medicine and Medical Research · pp. 895–902 · Published 10 Oct 2014
10.9734/BJMMR/2015/11451Abstract
Aims: This research was performed to evaluate the antioxidant and anti malarial activities of various catechins including catechin (C), epicatechin (EC), catechin-gallate (CG), gallocatechin-gallate (GCG), epigallocatechin (EGC), epicatechin-gallate (ECG), epigallocatechin gallate (EGCG). Study Design: The antioxidant activity was measured by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity and anti-malarial activity was determined by In vitro assay against P. falciparum culture, antioxidant activity was analyzed using linear regression analysis, and was continued by determining Inhibitory Concentration 50 (IC50). The anti-malarial activity was analyzed by probit analysis and IC50 determination. Place and Duration of Study: Medical Research Center, Faculty of Medicine, Maranatha Christian University, Bandung. Pharmacognicy Laboratory, Airlangga University, Surabaya. Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, Indonesia from March 2013 to October 2013. Results: The results showed that EC has the highest antioxidant activity with IC50 = 0.41μg/ml while ECG and GCG with IC50 = 0.52 μg/ml. For anti-malarial activity, CG has the highest anti malarial activity (IC50 = 0.37 μM). Conclusion: Catechins have high antioxidant activity and CG has highest anti-malarial activity.
References (30)
- 1 Antioxidant Determinations by the Use of a Stable Free Radical [DOI]
- 2 Green tea composition, consumption, and polyphenol chemistry [DOI]
- 3 Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions [DOI]
- 4 Vitamin C Equivalent Antioxidant Capacity (VCEAC) of Phenolic Phytochemicals [DOI]
- 5 Antioxidant Activity of Tea Polyphenols In Vivo: Evidence from Animal Studies [DOI]
- 6 The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention [DOI]
- 7 Artemisinin: mechanisms of action, resistance and toxicity [DOI]
- 8 Oxidative stress in malaria parasite-infected erythrocytes: host–parasite interactions [DOI]
- 9 Antioxidant Effects of Tea: Evidence from Human Clinical Trials [DOI]
- 10 Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men [DOI]
- 11 Artemisinin-based combination therapies (ACTs): Best hope for malaria treatment but inaccessible to the needy! [DOI]
- 12 Redox and antioxidant systems of the malaria parasite Plasmodium falciparum [DOI]
- 13 Pathogenesis of Cerebral Malaria: Recent Experimental Data and Possible Applications for Humans [DOI]
- 14 Antimalarial activity of medicinal plants used in traditional medicine in S. Tomé and Prıncipe islands [DOI]
- 15 Chemotherapy for Falciparum Malaria: The Armoury, the Problems and the Prospects [DOI]
- 16 The relation between single/double or repeated tea catechin ingestions and plasma antioxidant activity in humans [DOI]
- 17 Inducing the cell cycle arrest and apoptosis of oral KB carcinoma cells by hydroxychavicol: roles of glutathione and reactive oxygen species [DOI]
- 18 Catechins Delay Lipid Oxidation and alpha-Tocopherol and beta-Carotene Depletion Following Ascorbate Depletion in Human Plasma [DOI]
- 19 Antioxidant defense in Plasmodium falciparum--data mining of the transcriptome. [DOI]
- 20 Antimalarial properties of green tea [DOI]
- 21 Antioxidant, anticancer, and apoptosis-inducing effects of Piper extracts in HeLa cells [DOI]
- 22 Effect of water quality on the nutritional components and antioxidant activity of green tea extracts [DOI]
- 23 Consumption of green tea or green tea products: Is there an evidence for antioxidant effects from controlled interventional studies? [DOI]
- 24 Redox‐Dependent Apoptosis in Human Endothelial Cells after Adhesion of Plasmodium falciparum‐Infected Erythrocytes [DOI]
- 25 Antiplasmodial properties of some Malaysian medicinal plants.
- 26 Vitamin B6-Dependent Enzymes in the Human Malaria ParasitePlasmodium falciparum: A Druggable Target? [DOI]
- 27 Green tea exerts antioxidant action in vitro and its consumption increases total serum antioxidant potential in normal and dyslipidemic subjects [DOI]
- 28 Antioxidant and platelet aggregation inhibitor activities of black tea (Camellia sinensis L.) extract and fractions [DOI]
- 29 Comparison of effects of green tea catechins on apicomplexan hexose transporters and mammalian orthologues [DOI]
- 30 The role of ascorbic acid in the treatment of Plasmodium Berghei infected mice [DOI]
Cited by 24
Isidoro Riondato, Dario Donno, Alessandro Roman · Journal of Ethnopharmacology · 2019
Celestina I. Orabueze, Duncan A. Ota, Herbert A. Coker · Journal of Traditional and Complementary Medicine · 2020
Oluwole Solomon Oladeji, Abimbola Peter Oluyori, Deborah Temitope Bankole · Scientifica · 2020
Martha N. Ofokansi, Eze C. Nwoye, Chinenye J. Ugwah-Oguejiofor · Journal of Ethnopharmacology · 2024
Martha N. Ofokansi, Eze C. Nwoye, Chinenye J. Ugwah-Oguejiofor · 2023
José-Luis Rodríguez Rama, Natalia Mallo, Marco Biddau · Environmental Science and Pollution Research · 2020
Pierre Lutgen · Pharmacy & Pharmacology International Journal · 2018
Chinmay Pal · Biochemical Pharmacology · 2023
Showing 8 of 24 known citations — external sources report more than can currently be individually listed.
Related research
- In vitro Antioxidant and Anticancer Activity of Cyanobacteria — shares topic coverage
- Review: Parkia speciosa as Valuable, Miracle of Nature — shares topic coverage
- A Selective Review of Lipid Autoxidation and Rancidity, Antioxidants, and Dithiooxamide — shares topic coverage
- Antioxidant and Haemato-Biochemical Enhancing Properties of Daucus carota in Male Wistar Rats Toxicated with Lead Chloride — shares topic coverage
- Radical Scavenging Capacity and Efficacy of Myristica fragrans (Nutmeg) Metabolites on Cladosporum herbarum of Food Origin — shares topic coverage
Article metrics
Real usage data collected on this platform.
62
Page views
0
PDF downloads
35
Outbound clicks
24
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.