Antimicrobial Resistance of Klebsiella pneumoniae -ESBL Producing Strains Isolated from Clinical Specimens in Abidjan (Cote de Ivoire)
Joel Eric Tahou, Nathalie Kouadio Guessennd, Paulin Didier Sokouri, Valérie Gbonon, Fernique Konan, Jules Kouadio, Karine Kossia Gba, Baguy Mohamed Ouattara, Simon-Pierre Assanvo N’guetta
Microbiology Research Journal International · pp. 1–7 · Published 8 Jun 2017
10.9734/MRJI/2017/34085Abstract
Aims: The objective of this study is to detect the prevalence of qnr genes in broad-spectrum beta-lactamase producing Klebsiella pneumoniae, involved in hospital and community-acquired infections. Study Design: It is a retrospective study. Place and Duration of Study: Bacteriology and virology laboratorie of Institut Pasteur, Abidjan, Côte d'Ivoire. Methodology: From January 2011 to June 2016, 350 Klebsiella pneumoniae were isolated from various clinical specimens and identified by conventional bacteriological tests. Antibiotic resistance (beta-lactams, quinolones and aminoglycosides) and detection of broad-spectrum beta-lactamases were assessed by the diffusion method and the synergy test, respectively. Molecular characterization of quinolone resistance genes (qnr A, qnr B and qnr S) was performed by the conventional polymerase chain reaction (PCR). Results: Of the 350 Klebsiella pneumoniae isolates, 91(26%) were detected as ESBL producer, 36.2% (n=33) recovered from urine, 24.2% (n=22) from pus and 20.8% (n=19) from blood culture respectively. 46(33%) strains were idenifed to carry qnr genes, qnrB predominate 33(71%), followed by qnr 12(26.1%) and qnrA 1(2.2%). The strains exhibited high resistance to most of the agents tested, expect imipemen, low resistance to amikacin 4.1%, moderate to cefoxitin 31.8% and 54.9% with amoxicillin-clauvanic acid. Conclusion: Although these observed prevalences are small proportions, this can be seen as a warning signal for the future. The emergence and dissemination of resistance genes in Côte d'Ivoire could pose a public health problem. Thus, the establishment of a relevant resistance surveillance policy to better control the circulation of multidrug-resistant strains is necessary.
References (10)
- 1 Rapid Range Shifts of Species Associated with High Levels of Climate Warming [DOI]
- 2 Antibacterial resistance worldwide: causes, challenges and responses [DOI]
- 3 Plasmid-Mediated Quinolone Resistance [DOI]
- 4 Prevalence of qnr and aac(6')-Ib-cr Genes in Clinical Isolates of Klebsiella Pneumoniae from Imam Hussein Hospital in Tehran.
- 5 Prevalence of Plasmid‐Mediated Quinolone Resistance Genes among Ciprofloxacin‐Nonsusceptible Escherichia coli and Klebsiella pneumoniae Isolated from Blood Cultures in Korea [DOI]
- 6 Analysis of some common pathogens and their drug resistance to antibiotics [DOI]
- 7 Point-surveillance of antibiotic resistance in Enterobacteriaceae isolates from patients in a Lagos Teaching Hospital, Nigeria [DOI]
- 8 Mechanisms of Reduced Susceptibility to Ciprofloxacin in Escherichia coli Isolates from Canadian Hospitals [DOI]
- 9 The prevalence of plasmid-mediated quinolone resistance determinants among clinical isolates of ESBL or AmpC-producing Escherichia coli from Chinese pediatric patients [DOI]
- 10 ANTIBIOTIC SENSITIVITY PATTERNS OF ENTEROBACTERIACEAE ISOLATED AT KING FAISAL HOSPITAL, KIGALI - A THREE YEARS STUDY
Cited by 17
Djifahamaï Soma, Fatimata B. J. Diarra, Djibril Diallo · BMC Infectious Diseases · 2026
Ceren Başkan, Gözde F. Celebi · LWT · 2024
Maedeh Hoseinzadeh, M. Sedighi, Y. Yahyapour · Heliyon · 2024
W. Moussé, H. Sina, Victorien Dougnon · 2020
M. N. Tuo, A. Anoh, Zéphirin O. Wayoro · 2020
P. Ango, K. Konan, K. Kouame · 2019
Allepo Abe Innocent, Koffi Mathurin, D. Paulin · 2019
Eloise Müller-Schulte, M. N. Tuo, C. Akoua-Koffi · International Journal of Infectious Diseases · 2019
F. Salah, S. Soubeiga, A. Ouattara · Antimicrobial Resistance and Infection Control · 2019
Showing 9 of 17 known citations — external sources report more than can currently be individually listed.
Related research
- Molecular Detection of Extended Spectrum Beta-lactamase Resistance in Escherichia coli from Poultry Droppings in Keffi, Nigeria — shares topic coverage
- Antimicrobial Resistance in Primary Health Care Setting: The Prevalence of Multi-Drug Resistant Organisms in Health Centers under the Primary Health Care Corporation PHCC, Qatar — shares topic coverage
- Evaluation of Multi-drug Resistant Bacteria and High Risk of Contamination in Ready to Eat Fruits in Kano Metropolis — shares topic coverage
- Effect of Misuse of Antibiotics on Cytokine Patterns and Antibiogram of Bacteria Isolates from Surgical Site Infection in Benin City, Edo State, Nigeria — shares topic coverage
- Prevalence and Susceptibility Analysis of Carbapenem Resistant Gram-negative Pathogens in Super Specialty Tertiary Care Center, Mumbai, India — shares topic coverage
Article metrics
Real usage data collected on this platform.
64
Page views
0
PDF downloads
12
Outbound clicks
17
Citations
Views over time
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
Traffic sources
Referring site, by host.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.