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Research Article Open access CC BY 3.0

Antimicrobial Resistance in Pathogens Causing Pediatrics Bloodstream Infections in a Saudi Hospital

Maha A. Abo-Shadi, Aisha A. Al-Johani, Ahmad A. Bahashwan

Microbiology Research Journal International · pp. 212–227 · Published 19 Dec 2012

10.9734/BMRJ/2012/2033

Abstract

Background: Bloodstream infection (BSI) is one of the most common life-threatening conditions in hospitalized pediatrics especially if associated with resistant microbes. Aims: To determine the incidence, predisposing factors, microbiological and antimicrobial resistance patterns in suspected BSI pediatric patients in a Saudi hospital. Place and Duration of Study: Different wards of Madinah Maternity and Children's Hospital, Saudi Arabia, during one year period from July 1, 2009 to June 30, 2010. Methodology: Blood cultures were performed to all cases (n= 11968) using Bactec 9240 instrument Blood Culture Systems. Microorganisms were identified by colony morphology, Gram stain and biochemical profiles. BD Phoenix™ was used in confirmation of identification of all BSI Gram-negative isolates. Antibiotic susceptibility pattern of isolates was further done by using disk diffusion method. Results: 728 cases (6.1%) were diagnosed with BSI after having a one positive blood culture. The overall mortality rate was 11%. Gram-positive, Gram-negative and yeast accounted for 63.8%, 31.6% and 4.6% of the total isolates, respectively. Coagulase-negative staphylococci were the most prevalent Gram-positive isolates (44%); while Serratia marcescens and Klebsiella pneumoniae were the most common Gram-negatives. Gram-positive bacteria were mostly sensitive to cephalothin (82.3%) and vancomycin (72.2%), while Gram-negative bacteria were mostly sensitive to ciprofloxacin (93%), piperacillin/tazobactam (92.9%), and meropenem (89.8%). Conclusion: The incidence rate of BSI is highest in ICU neonates. Therefore, special attention should be given to the quality of care provided for them to improve safety. There was appreciable resistance to commonly used antibiotics; and continued monitoring of antibiotic resistance is of great importance to ensure the proper use of antibiotics and to detect any increasing trends in resistance.

Bloodstream infections pediatrics antimicrobial resistance Saudi Arabia

References (35)

  1. 1 National Epidemiology of Mycoses Survey (NEMIS): Variations in Rates of Bloodstream Infections Due to Candida Species in Seven Surgical Intensive Care Units and Six Neonatal Intensive Care Units [DOI]
  2. 2 Nosocomial bloodstream infections in pediatric patients in United States hospitals: epidemiology, clinical features and susceptibilities [DOI]
  3. 3 Antimicrobial resistance predicts death in Tanzanian children with bloodstream infections: a prospective cohort study [DOI]
  4. 4 Prevalence of extended-spectrum β-lactamase-producing Gram-negative bacteria in septicaemic neonates in a tertiary care hospital [DOI]
  5. 5 Rapid Detection of Microorganisms in Blood Cultures of Newborn Infants Utilizing an Automated Blood Culture System [DOI]
  6. 6 Chryseobacterium (Flavobacterium) meningosepticum outbreak associated with colonization of water taps in a neonatal intensive care unit [DOI]
  7. 7 Bacterial Bloodstream Infections in Neonates in a Developing Country [DOI]
  8. 8 Coagulase-Negative Staphylococcal Bacteremia [DOI]
  9. 9 Occurrence of nosocomial bloodstream infections in six neonatal intensive care units [DOI]
  10. 10 A changing pattern of susceptibility of Xanthomonas maltophilia to antimicrobial agents: implications for therapy [DOI]
  11. 11 Detection and Treatment of Bloodstream Infection: Laboratory Reporting and Antimicrobial Management [DOI]
  12. 12 Nosocomial Bloodstream Infections: Organisms, Risk Factors, and Implications [DOI]
  13. 13 Rate, Risk Factors, and Outcomes of Nosocomial Primary Bloodstream Infection in Pediatric Intensive Care Unit Patients [DOI]
  14. 14 Controlled evaluation of BacT/Alert standard aerobic and FAN aerobic blood culture bottles for detection of bacteremia and fungemia [DOI]
  15. 15 Risk factor analysis of blood stream infection and pneumonia in neutropenic patients after peripheral blood stem-cell transplantation [DOI]
  16. 16 Initial Concentration of Staphylococcus epidermidis in Simulated Pediatric Blood Cultures Correlates with Time to Positive Results with the Automated, Continuously Monitored BACTEC Blood Culture System [DOI]
  17. 17 Antimicrobial resistance in pathogens causing nosocomial bloodstream infections in university hospitals in Egypt [DOI]
  18. 18 Emergence of methicillin resistant Staphylococcus aureus (MRSA) bacteraemia among children in England and Wales, 1990-2001 [DOI]
  19. 19 Impact of Multiresistance of Gram-negative Bacteria in Bloodstream Infection on Mortality Rates and Length of Stay [DOI]
  20. 20 Five-year evaluation of the antimicrobial susceptibility patterns of bacteria causing bloodstream infections in Iran [DOI]
  21. 21 Nosocomial blood stream infection in intensive care units at Assiut University Hospitals (Upper Egypt) with special reference to extended spectrum β-lactamase producing organisms [DOI]
  22. 22 Serratia marcescens-contaminated baby shampoo causing an outbreak among newborns at King Abdulaziz University Hospital, Jeddah, Saudi Arabia [DOI]
  23. 23 Nosocomial infections in a neonatal intensive care unit in south-western Saudi Arabia [DOI]
  24. 24 Four year prospective evaluation of nosocomial bacteremia: epidemiology, microbiology, and patient outcome [DOI]
  25. 25 A 7-year study of bloodstream infections in an English children?s hospital [DOI]
  26. 26 Occurrence and antimicrobial resistance of Gram-negative bacteria isolated in haemodialysis water and dialysate of renal units: results of a Greek multicentre study [DOI]
  27. 27 Half a Decade of Neonatal Sepsis, Riyadh, Saudi Arabia [DOI]
  28. 28 Frequency and antimicrobial susceptibility patterns of bacterial pathogens isolated from septicemic patients in Makkah hospitals [DOI]
  29. 29 Enterobacter cloacae: a predominant pathogen in neonatal septicaemia.
  30. 30 Risk factors for bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae [DOI]
  31. 31 Antibiotic Susceptibility and Outer Membrane Proteins of Clinical Xanthomonas maltophilia Isolates [DOI]
  32. 32 Epidemiology of polyclonal gram-negative bacteremia [DOI]
  33. 33 Bacteremia in children at the University Hospital in Riyadh, Saudi Arabia [DOI]
  34. 34 Bacterial isolates from fatal cases of bloodstream infections at a university hospital in Central, Saudi Arabia. [DOI]
  35. 35 Bloodstream Infection and Endocarditis [DOI]

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