Antifungal Susceptibility Patterns of Vulvovaginal Candida species among Women Attending Antenatal Clinic at Mbarara Regional Referral Hospital, South Western Uganda
Kiguli James Mukasa, Itabangi Herbert, Atwine Daniel, Kibuka Livingstone Sserunkuma, Bazira Joel, Byarugaba Frederick
Microbiology Research Journal International · pp. 322–331 · Published 6 Nov 2014
10.9734/BMRJ/2015/13804Abstract
Aims: To identify the Candida species that cause vulvovaginal candidiasis and determine their antifungal susceptibility patterns. Study Design: This was a cross-sectional study. Place and Duration of Study: The study was conducted at the antenatal clinic of Mbarara Regional Referral Hospital in Mbarara Municipality, between December 2012 and February 2013. Methods: High vaginal swabs from 456 pregnant women were subjected to microscopy and culture on Sabouraud Dextrose Agar. Candida isolates were identified by the germ tube and Analytical profile index (API® Candida) tests. Susceptibility to fluconazole, itraconazole and voriconazole was determined by the Etest strips and for clotrimazole and nystatin by the disc diffusion method on Mueller Hinton agar supplemented with 2%w/v glucose and 0.5µg/ml methylene blue dye. Results: Of the 456 High vaginal swabs cultured, 207 grew Candida species. Species distribution was as follows: C. albicans (78.95%), C. glabrata (14.35%), C. krusei (3.35%), C. tropicalis (1.44%), C. famata (0.96%), C. parapsilosis (0.48%) and C. lusitaniae (0.48%). Resistance to nystatin was only observed in 0.61% of C.albicans. Resistance to clotrimazole was observed in 50%, 36.67% and 0.61% of C. famata, C. glabrata and C. albicans respectively. C. krusei showed a high resistance of 71.43% to fluconazole. C. glabrata, C. krusei, C. famata and C. lusitaniae exhibited 100% resistance to itraconazole. Resistance to voriconazole of less than 11% was exhibited by only C. albicans and C. glabrata. Conclusion: C.albicans was susceptible to most antifungal agents tested except itraconazole and voriconazole. All isolates were susceptible to nystatin except less than 1% of Candida albicans. Non-albicans demonstrated resistance to some drugs especially itraconazole. We recommend use of Nystatin for empirical management of vulvovaginal candidiasis among pregnant women.
References (23)
- 1 4 million neonatal deaths: When? Where? Why? [DOI]
- 2 Vulvovaginal candidosis [DOI]
- 3 Microbial Prevalence, Diversity and Abundance in Amniotic Fluid During Preterm Labor: A Molecular and Culture-Based Investigation [DOI]
- 4 Antifungal Susceptibility Testing: Practical Aspects and Current Challenges [DOI]
- 5 Antifungal Susceptibilities of Candida Species Causing Vulvovaginitis and Epidemiology of Recurrent Cases [DOI]
- 6 Method for antifungal disk diffusion susceptibility testing of yeasts : Approved guideline
- 7 Prevalence and risk factors for vaginal Candidacolonization in women with type 1 and type 2 diabetes [DOI]
- 8 Antifungal susceptibility testing [DOI]
- 9 Vulvovaginal carriage of yeasts other than Candida albicans [DOI]
- 10 Antifungal Susceptibility Testing: Technical Advances and Potential Clinical Applications [DOI]
- 11 Fluconazole Susceptibility of Vaginal Isolates Obtained from Women with Complicated Candida Vaginitis: Clinical Implications [DOI]
- 12 Prevalence of and risk factors for fungal vaginitis caused by non-albicans species [DOI]
- 13 The distribution frequency of Candida species in the genitourinary tract among symptomatic individuals in Nigerian cities.
- 14 Prevalence & susceptibility to fluconazole of Candida species causing vulvovaginitis.
- 15 [Prevalence of vaginal candidiasis in pregnant women. Identification of yeasts and susceptibility to antifungal agents].
- 16 ANTIFUNGAL SUSCEPTIBILITY TESTING [DOI]
- 17 [Vaginal candidiasis: etiology and sensitivity profile to antifungal agents in clinical use].
- 18 Species Distribution and Susceptibility to Azoles of Vaginal Yeasts Isolated Prostitutes [DOI]
- 19 Vulvovaginal candidiasis in Mato Grosso, Brazil: pregnancy status, causative species and drugs tests [DOI]
- 20 Host defense against oropharyngeal and vaginal candidiasis: Site-specific differences.
- 21 Premature delivery due to intrauterine Candida infection that caused neonatal congenital cutaneous candidiasis: A case report [DOI]
- 22 CLINICAL RELEVANCE OF ANTIFUNGAL RESISTANCE [DOI]
- 23 Species distribution and antifungal sensitivity patterns of vaginal yeasts [DOI]
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