Antifungal Activity of Flavonoid Isolated from Lindernia crustacea (L) F. Muell against  Traditionally Claimed Dermatophytes

Smriti Rekha Chanda Das; Abdul Baquee Ahmed; Dibyendu Shil; Trishna Das; Faruk Alam; Jashabir Chakraborty

doi:10.9734/jpri/2021/v33i46B32970

Research Article Open access CC BY 4.0

Antifungal Activity of Flavonoid Isolated from Lindernia crustacea (L) F. Muell against Traditionally Claimed Dermatophytes

Smriti Rekha Chanda Das, Abdul Baquee Ahmed, Dibyendu Shil, Trishna Das, Faruk Alam, Jashabir Chakraborty

Journal of Pharmaceutical Research International · pp. 512–521 · Published 23 Oct 2021

10.9734/jpri/2021/v33i46B32970

Abstract

Aim: The present study was aimed to establish antifungal activity of flavonoid isolated from Lindernia crustacea (L) F. Muell. Methods: Potent bioactive constituent from benzene extract was isolated through flash chromatography with solvent Toluene and Acetic acid (4:1). Isolated compound was structurally established by spectroscopic method. Antifungal potential of benzene extract as well as isolated compound was tested by disc diffusion method against two fungal strains Candida albicans (C. albicans) and Trichophyton rubrum (T. rubrum). Results: The isolated compound from benzene extract was found to be flavonoid. Benzene extract as well as flavonoid were shown remarkable zone of inhibition against both fungal strains which indicates strong antifungal activity. Conclusion: The experimental results concluded that Lindernia crustacea (L) F. Muell have significant anti fungal activity due to flavonoid content. It is expected that the results of the present research work would be beneficial in establishing the scientific basis of the traditional claims of medicinal values of Lindernia crustacea.

Lindernia crustacea (L) F benzene extract isolation flavonoid antifungal activity

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Smriti Rekha Chanda Das, Abdul Baquee Ahmed, Dibyendu Shil, Trishna Das, Faruk Alam, Jashabir Chakraborty (2021). Antifungal Activity of Flavonoid Isolated from Lindernia crustacea (L) F. Muell against Traditionally Claimed Dermatophytes. Journal of Pharmaceutical Research International , 512–521. https://doi.org/10.9734/jpri/2021/v33i46B32970

Affiliations

Smriti Rekha Chanda Das — Department of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam - 781017, India.
Abdul Baquee Ahmed — Department of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam - 781017, India.
Dibyendu Shil — Department of Pharmacognosy, Mata Gujri College of Pharmacy, Mata Gujri University, Purabpali Road, Kishanganj, Bihar - 855107, India.
Trishna Das — Department of Pharmaceutical Chemistry, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam - 781017, India.
Faruk Alam — Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam - 781026, India.
Jashabir Chakraborty — Department of Pharmacognosy, Mata Gujri College of Pharmacy, Mata Gujri University, Purabpali Road, Kishanganj, Bihar - 855107, India.

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