Antidiabetic and Toxicity Studies of the Extract of Four Nigerian Medicinal Plants
Oyenike Idayat Bello, Marcus Durojaye Ayoola, Oluwafunke Obembe, Kemi Feyisayo Akinwunmi
European Journal of Medicinal Plants · pp. 32–45 · Published 12 Nov 2022
10.9734/ejmp/2022/v33i111107Abstract
Aims: To evaluate the anti-hyperglycaemic efficacy and safety of the methanol extract of the combination of Senecio biafrae leaf, Xylopia aethiopica fruit, Carica papaya seed and Spondias mombin stem bark mixed together in ratio 1:1:1:1 Study Design: Extract of medicinal plants was assayed using glucose and streptozotocin-induced herperglycaemic rats model. Place and Duration of Study: Department of Pharmacognosy, Obafemi Awolowo University, IleIfe, Nigeria, between May, 2019 and January, 2022. Methodology: The extract of the combined plant parts was tested for toxicity in rats while its effects on glucose level, blood and biochemical components were also assessed. Its in-vitro anti-hyperglycaemic activity was assayed in α-amylase and α-glucosidase inhibitory models while its in-vivo effects were tested in glucose and streptozotocin-induced hyperglycaemic rats. The antioxidant activity of the extract was also carried out. Results: The extract did not show any adverse effects on blood sugar levels, haematological and biochemical parameters in normal rats in sub acute toxicity tests. The extract gave comparable (p > 0.05) α-amylase and α-glucosidase inhibitory effects to acarbose. In glucose-induced hyperglycaemic rats, its 100 mg/kg was the most effective dose with 19, 40, 43, and 57% activity that was significantly higher (p < 0.05) than the 10, 18, 24, and 40% activity given by glibenclamide (5 mg/kg) at the same time points. In streptozotocin-induced diabetic assay, its 50 mg/kg showed 31, 85, 85 and 82 % effects on days 4, 7, 10 and 14, respectively that was significantly higher than its 100 mg/kg and glibenclamide on days 7 and 10. The extract also elicited high free radical scavenging effects in all the antioxidant assays. Conclusion: The extract of the combination of four Nigerian antidiabetic plants mixed together in equal ratio gave significantly better antidiabetic activity at low doses than the individual plants without toxic effects.
References (49)
- 1 Use of a free radical method to evaluate antioxidant activity [DOI]
- 2 [14] Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent [DOI]
- 3 International Diabetes Federation 2017 [DOI]
- 4 The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals [DOI]
- 5 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2022 [DOI]
- 6 Chemical Biology of Peroxynitrite: Kinetics, Diffusion, and Radicals [DOI]
- 7 African Indigenous Vegetables: An overview of the cultivated species.
- 8 Industrial solvents and liver toxicity: Risk assessment, risk factors and mechanisms [DOI]
- 9 Herb-Herb Combination for Therapeutic Enhancement and Advancement: Theory, Practice and Future Perspectives [DOI]
- 10 Inventory of antidiabetic plants in selected districts of Lagos State, Nigeria [DOI]
- 11 Critical evaluation of the role of acarbose in the treatment of diabetes: patient considerations [DOI]
- 12 Preliminary studies on the inorganic constituents of some indigenous hypoglycaemic herbs on oral glucose tolerance test [DOI]
- 13 Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: Anti-trichomonal, antidiabetic, anti-inflammatory, hepatoprotective and antioxidant effects [DOI]
- 14 Glibenclamide: an old drug with a novel mechanism of action? [DOI]
- 15 Recommended Testing in Diabetes Research [DOI]
- 16 Phytochemical study and anti-inflammatory and antioxidant potential of Spondias mombin leaves [DOI]
- 17 Acute toxicity study of Carica papaya leaf extract in Sprague Dawley rats [DOI]
- 18 Hepatoprotective potential of polyphenol rich extract of Murraya koenigii L.: An in vivo study [DOI]
- 19 Detailed Dissection of a New Mechanism for Glycoside Cleavage: α-1,4-Glucan Lyase [DOI]
- 20 Characterization of the antiproliferative activity of Xylopia aethiopica [DOI]
- 21 Efficacy of Composite Extract from Leaves and Fruits of Medicinal Plants Used in Traditional Diabetic Therapy against Oxidative Stress in Alloxan-Induced Diabetic Rats [DOI]
- 22 Effects of Aqueous Extract of Mangifera indica L. (Mango) Stem Bark on Haematological Parameters of Normal Albino Rats [DOI]
- 23 Effect of a poly-herbal formulation, Okudiabet, on alloxan-induced diabetic rats.
- 24 Traditional management of tuberculosis in Ogun State of Nigeria: the practice and ethnobotanical survey [DOI]
- 25 Synergistic postprandial blood glucose modulatory properties of Vernonia amygdalina (Del.), Gongronema latifolium (Benth.) and Occimum gratissimum (Linn.) aqueous decoctions [DOI]
- 26 Effect of Methanol Extract of Telfairia occcidentalis on Haematological Parameters in Wister Rats [DOI]
- 27 Performance and haematological indices in rats exposed to monocrotophos contamination [DOI]
- 28 Botanical galactogogues: nutritional values and therapeutic potentials [DOI]
- 29 Informant consensus selection method: a reliability assessment on medicinal plants used in north western Nigeria for the treatment of diabetes mellitus. [DOI]
- 30 Effects of an Herbal Combination on Glycemic Control and Lipid Profile in Diabetic Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial [DOI]
- 31 Evaluation of mosquito larvicidal effect of Carica Papaya against Aedes Aegypti
- 32 Antioxidant potential of Xylopia aethiopica fruit acetone fraction in a type 2 diabetes model of rats [DOI]
- 33 Effect of aqueous leaf extract of Senecio biafrae on hyperglycaemic and serum lipid profile of alloxan-induced diabetic rats
- 34 Pharmacological Management of Diabetes Mellitus.
- 35 Isolation and characterization of 2-hydroxy-3-[4-hydroxyphenyl]-2-propenoic acid and 4-bromophenol from anti-diabetic extract of the root bark of Uvaria afzelii [DOI]
- 36 Antihyperglycaemic and Anti-oxidant Activities of Eugenia uniflora Leaf: Evaluation of Ethnomedical Claims IV [DOI]
- 37 Anti-hyperglycaemic and anti-oxidant activities of five Nigerian antidiabetic plants [DOI]
- 38 Median Lethality Dose of Xylopia aethiopica Fruit Ethanol Extract [DOI]
- 39 Bidirectional graft-host hematological traffic in liver transplantation [DOI]
- 40 Justifying Antidiabetic Ethnomedicinal Claim of Senecio biafrae through Its Antihyperglycemic and Anti-Oxidant Activities
- 41 HAEMATOLOGICAL RESPONSE TO INTAKE OF UNRIPE CARICA PAPAYA FRUIT EXTRACT AND THE ISOLATION AND CHARACTERIZATION OF CARICAPINOSIDE: A NEW ANTISICKLING AGENT FROM THE EXTRACT
- 42 Effects of combined leaf extract of Vernonia amygdalina and Azadirachta indica on hepatic morphology and hepatotoxicity markers in streptozotocin-induced diabetic rats [DOI]
- 43 Anti-diabetic Activity of Convallatoxin Isolated from the Root Bark of Parquetina nigrescens (Afzel.) Bullock (Asclepiadaceae) [DOI]
- 44 Hyperglycaemia Lowering Effect of Kaurane Diterpenoids from the Fruits of Xylopia aethiopica (A. Dunal) Rich
- 45 Antihyperglycaemic and antioxidant activities of Sansevierialiberica as justification for its antidiabetic claims [DOI]
- 46 ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACTS OF SPONDIAS MOMBIN (ANACARDIACEAE) STEM BARK ON ALLOXAN-INDUCED DIABETIC RATS
- 47 Asian Journal of Biochemical and Pharmaceutical Research [DOI]
- 48 Medicinal Plants Used in Four Local Government Areas of Southwestern Nigeria for the Management of Diabetes and Its Comorbidities: An Ethnobotanical Survey [DOI]
- 49 Hepatobiliary Surgery and Nutrition [DOI]
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