Anti-Inflammatory and Antitussive Activity of Asthpadose, a Phytomedicine used in the Treatment of Asthma in Côte d'Ivoire
BAIBO Guy Léonce, Ackah Jacques Auguste Alfred Bognan, Brahima Kouamé Koffi Raoul, Yayé Yapi Guillaume, Obouayeba Abba Pacôme
Asian Journal of Research in Biochemistry · pp. 49–59 · Published 25 May 2024
10.9734/ajrb/2024/v14i4293Abstract
Introduction: The aim of this study is to contribute to the valorisation of an anti- asthmatic phytomedicine (Asthpadose) traditionally used in Côte d'Ivoire. Aims: Evalute antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was. Methodology: The antiasthma’s activity of the aqueous extract of Asthpadose (EAA) was evaluated by the determining of its anti-inflammatory activity using the carrageenan oedema induction method. This anti-asthmatic activity was also evaluated by its antitussive action on the frequency of cough induced in rats exposed to liquid ammonia. Results: The results revealed that EAA showed a very significant strong anti- inflammatory activity with an oedema inhibition rate ranging from 34.29% to 70.9 5%. This activity was much better than that of diclofenac sodium (a reference molecule against inflammation) with an oedema inhibition rate ranging from 12.24% to 58.39%. As for its antitussive activity, the results also showed good antitussive activity of the extract. EAA presented a cough inhibition rate of 74.22% compared to 58.76% for dextrometaphan which is also a reference molecule against cough. Conclusion: This observed activity could therefore justify the use of Asthpadose in the treatment of asthma which is a disease manifested by inflammation and cough. In view of the very promising results of this study, it would therefore be necessary to continue studies on this phytomedicine to understand its mechanism of action on asthma.
References (16)
- 1 Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial [DOI]
- 2 Opiate Therapy in Chronic Cough [DOI]
- 3 Modulation of inflammation and immunity by dietary conjugated linoleic acid [DOI]
- 4 Nature of airway inflammation and remodeling in chronic cough [DOI]
- 5 Aqueous extract of Codium fragile suppressed inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and carrageenan-induced rats [DOI]
- 6 Modulation of interleukin expression by medicinal plants and their secondary metabolites: A systematic review on anti-asthmatic and immunopharmacological mechanisms [DOI]
- 7 Pattern differences in experimental fevers induced by endotoxin, endogenous pyrogen, and prostaglandins [DOI]
- 8 Antitussive effects of nasal thymol challenges in healthy volunteers [DOI]
- 9 EVALUATION OF ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF TAMARINDUS INDICA SEEDS [DOI]
- 10 The anti-inflammatory effects of Caragana tangutica ethyl acetate extract [DOI]
- 11 Anatomy and neuro-pathophysiology of the cough reflex arc [DOI]
- 12 Evaluation of Analgesic and Anti-inflammatory Activities and Phytochemical Screening of the Leaves Extract of Paullinia Pinnata (Sapindaceae)
- 13 Plants in Respiratory Disorders II- Antitussives, A Review [DOI]
- 14 Évaluation de l’activité antiasthmatique et antitussive de Combretum molle, plante médicinale de la pharmacopée ivoirienne [DOI]
- 15 Dictionnaire de l’Appareil Respiratoire [DOI]
- 16 Phytochemical Methods. A Guide to Modern Techniques of Plant Analysis. [DOI]
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