Analgesic and Anti-inflammatory Activities of Triterpenoid Molecules Isolated from the Leaves of Combretum glutinosum Perr. Ex DC (Combretaceae)
Madièye Sene, Daouda Ndiaye, Abdoulaye Gassama, Firmin Sylva Barboza, Mbaye Diagne Mbaye, S. Y. Guata Yoro
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–8 · Published 6 Mar 2019
10.9734/jamps/2018/v19i430096Abstract
Combretum glutinosum Perr. Ex DC (COMBRETACEAE) is a traditional medicinal plant, widely distributed in Senegal and Africa. The aim of that study was to investigate the analgesic and anti-inflammatory activities of two triterpenes, betulonic acid (DN7) and cabraleone (DN12), isolated from the leaves of Combretum glutinosum. Experiments were performed in acetic acid-induced contortions in mice and carrageenan rat paw oedema. DN7 (3 mg/kg, per os) and DN12 (3 mg/kg, per os) significantly prevent contortions in mice. The number of contortions is respectively 30±10 and 32±7 versus 72.6±6.64 in control group (p<0.05, n=5). DN7 (3 mg/kg, per os) significantly prevented the increased rat paw oedema (31.84±6.76 vs 92.72±6.05%) (p<0.05, n=5). DN12 (10 mg/kg, per os) induced rat paw oedema prevention similar to that of acetylsalicylic acid (10 mg/kg, per os) administered in the same conditions (29.28±5.88 vs 30.96±7.25%; ns, n=5). The analgesic and anti-inflammatory activities of triterpenes isolated from C. glutinosum leaves are similar to those of non-steroidal anti-inflammatory drugs such acetylsalicylic acid, justifying the use of this plant in traditional medicine to manage pain and inflammation.
References (14)
- 1 Cyclooxygenases: Structural, Cellular, and Molecular Biology [DOI]
- 2 ACETIC ACID FOR ANALGESIC SCREENING
- 3 The Pentacyclic Triterpenoids in Herbal Medicines and Their Pharmacological Activities in Diabetes and Diabetic Complications [DOI]
- 4 Molecular Basis of the Anti-Inflammatory Effects of Terpenoids [DOI]
- 5 Antifungal activities of seven West African Combretaceae used in traditional medicine [DOI]
- 6 Beneficial health effects of lupenone triterpene: A review [DOI]
- 7 Hepatoprotective natural triterpenoids [DOI]
- 8 Ursolic Acid fromPlantagomajor, a Selective Inhibitor of Cyclooxygenase-2 Catalyzed Prostaglandin Biosynthesis [DOI]
- 9 Tetra- and Pentacyclic Triterpene Acids from the Ancient Anti-inflammatory Remedy Frankincense as Inhibitors of Microsomal Prostaglandin E 2 Synthase-1 [DOI]
- 10 Antimalarial activity of Swartzia madagascariensis desv. (leguminosae), Combretum glutinosum guill. & perr. (combretaceae) and Tinospora bakis miers. (menispermaceae), Burkina Faso medicinal plants [DOI]
- 11 Contribution à la connaissance des plantes médicinales utilisées dans les soins infantiles en pays San, au Burkina Faso [DOI]
- 12 Phytochemical Screening, Evaluation of Antioxidant and Anti-sickling Activities of Two Polar Extracts of Combretum glutinosum Leaves. Perr. ex DC [DOI]
- 13 Richesse de la pharmacopée malinké : rôle médicinal de l’arbre a Khossanto : (Kédougou, Sénégal oriental) [DOI]
- 14 Contribution à l'étude des combretaceae dans les formations végétales de la région est du Burkina Faso
Cited by 7
Yoro Tine, Madièye Sene, Khadidiatou Thiam · International Journal of Biological and Chemical Sciences · 2024
Mamadou Aliou Baldé, Emmy Tuenter, Mohamed Sahar Traoré · Journal of Ethnopharmacology · 2020
Madièye Sene, Yoro Tine, Faty Keïta · Journal of Phytomoleculs and Pharmacology · 2023
Showing 3 of 7 known citations — external sources report more than can currently be individually listed.
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