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An in Vivo Evaluation of the Hepatoprotective Potential of Triphala in CCl4 Induced Hepatic Injured Rodent Model

Faisal Ahmed Nadvi, Rifat Ara Nisu, Sabnam Roy Suma, Ankita Bose, Md. Rafat Tahsin, Md. Shah Amran

Journal of Complementary and Alternative Medical Research · pp. 51–59 · Published 25 Oct 2023

10.9734/jocamr/2023/v24i2498

Abstract

Liver injury, also known as hepatotoxicity, is a serious health concern since it can irreversibly harm this significant organ's function, leading to life-threatening liver cirrhosis or liver failure. Natural medicinal plants have long been known to play essential roles in up-to-date medication discovery and they are considered as enormous sources of treatment now. Regarding the critical situation of hepatotoxic patients around the globe, among numerous plants with numerous potentials, “Triphala” is a popular and highly effective, strong Ayurvedic and Indian traditional medication with exclusive hepatoprotective and antioxidant properties. Triphala is a Sanskrit word that means three fruits and so, as the name, it is a mixture of an equal amount of the dried fruits of three plants: Emblica officinalis (Amalaki), Terminalia chebula (Haritaki) and Terminalia bellerica (Bibhitaki). In this experiment, carbon tetrachloride (CCl4) was used to induce hepatotoxicity and then the hepatoprotective activity of Triphala was assessed through determining the results of different parameters. Afterward observing the results, it was found that the plant can effectively reverse the disturbed pathological state toward healthy status to a different extent in a dependent manner. Here both medium dose and high dose can significantly reverse (p<0.05) the disturbed pathological state towards a healthy pathological state. Moreover, any safety concern or possibility of side effects was not aroused throughout the investigation. Therefore, Triphala is considered to have a major aptitude towards hepatic protection and can be counted as an alternative to the marketed synthetic drug, silymarin, with more safety and quite equal efficacy. To conclude, more vigorous future study is needed so that this promising plant can be incorporated into the hepatotoxic treatment arena.

Liver injury triphala CCl4 silymarin antioxidant

References (21)

  1. 1 Update on global epidemiology of viral hepatitis and preventive strategies [DOI]
  2. 2 Antioxidant Effects of Aqueous Extract of Terminalia chebula in Vivo and in Vitro [DOI]
  3. 3 Beneficial drugs for liver diseases [DOI]
  4. 4 Selected hepatoprotective herbal medicines: Evidence from ethnomedicinal applications, animal models, and possible mechanism of actions [DOI]
  5. 5 Medicinal plants with hepatoprotective activity in Iranian folk medicine [DOI]
  6. 6 Scientific validation of the ethnomedicinal properties of the Ayurvedic drug Triphala: A review [DOI]
  7. 7 Pharmacotherapies for Drug-Induced Liver Injury: A Current Literature Review [DOI]
  8. 8 Immunomodulatory effects of triphala and its individual constituents: a review.
  9. 9 Hepatoprotective Activity of Some Medicinal Plants in Sudan [DOI]
  10. 10 Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds [DOI]
  11. 11 ANTIOXIDANT AND HEPATOPROTECTIVE EFFECTS OF BAUHINIA RACEMOSA AGAINST PARACETAMOL AND CARBON TETRACHLORIDE INDUCED LIVER DAMAGEIN RATS
  12. 12 Triphala and Its Active Constituent Chebulinic Acid Are Natural Inhibitors of Vascular Endothelial Growth Factor-A Mediated Angiogenesis [DOI]
  13. 13 In Vitro Bioaccessibility, Human Gut Microbiota Metabolites and Hepatoprotective Potential of Chebulic Ellagitannins: A Case of Padma Hepaten® Formulation [DOI]
  14. 14 Hepatotoxicity: Treatment, causes and applications of medicinal plants as therapeutic agents [DOI]
  15. 15 Hepatoprotective Activities of Triphala and Its Constituents
  16. 16 Review of plants with hepatoprotective activity evaluated in Mexico
  17. 17 Study of the safety of oral Triphala aqueous extract on healthy volunteers [DOI]
  18. 18 Antioxidant Effect of Triphala - Critical Review [DOI]
  19. 19 An Overview of Triphala Guggulu and its Ingredients [DOI]
  20. 20 In vivo Assessment of Antidiabetic Potential and Mapping of Pharmacological Properties of Ethanolic Extract of Leaves of Coccinia grandis on Alloxan-induced Diabetic Rats [DOI]
  21. 21 Asian Journal of Medical Principles and Clinical Practice [DOI]

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