An Improved Commercially Feasible Process for Flecainide Acetate
Nilesh Takale, Neelakandan Kaliyaperumal, Gopalakrishnan Mannathusamy, Rajarajan Govindasamy
Journal of Pharmaceutical Research International · pp. 421–430 · Published 15 Oct 2021
10.9734/jpri/2021/v33i46A32885Abstract
Commercially viable manufacturing process for Flecainide Acetate (I) conforming to regulatory specification and cost effective process is reported. Specifically, an improved process for the preparation of Flecainide Acetate allows isolation of anhydrous hydrochloride salt of Compound III, which facilitates the reduction of the pyridine ring with the only catalytic amount of platinum on carbon within 2 hours Therefore, simplifies the synthesis and isolation of Flecainide acetate on a commercial scale to a considerable extent.
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