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Ameliorating Effects of Solanum anomalum Thonn. Ex. Schumach Fruit Extracts on Paracetamol-induced Kidney Injuries and Haemato-biochemical Indices in Rats

Samuel J. Offor, Sifon Obong J. Akpan, Adedayo A. Tologbonse, Romanus A. Umoh, Daniel F. Akpan

Journal of Complementary and Alternative Medical Research · pp. 37–45 · Published 17 Jan 2022

10.9734/jocamr/2022/v17i130325

Abstract

Paracetamol (acetaminophen) is a widely used non-opioid analgesic and antipyretic drug that is safe at therapeutic doses but toxic to the liver and kidneys in overdose. Although the risk of paracetamol-induced liver injury is much higher than in the kidneys, incidents of kidney damage by paracetamol should not be ignored, given the enormous cost of treating kidney diseases, particularly in resource-challenged developing nations. In an onerous quest for a cheaper and readily available antidote, this study examined the effect of Solanum anomalum fruit extract on paracetamol-induced kidney injuries and haemato-biochemical indices in rats. Twenty-five mature albino rats of both sexes were used, divided into five groups of five rats per group. Group 1 (normal control) rats were given distilled water (10ml/kg) for 8 days, group 2 (negative control) given distilled water (10 ml/kg) for 8 days, group 3 (positive control) given 100 mg/kg Silymarin for 8 days, group 4 given 452 mg/kg of S. anomalum fruit extract for 8 days, and group 5 given 678 mg/kg of S. anomalum fruit extract for 8 days. Thereafter, 2.0 g/kg of paracetamol was administered to groups 2-5 orally on the 8th day. Rats in group 2 showed significant increases in urea, creatinine, sodium ion, total WBCs, decrease in PCV, Hb concentration and RBCs. Administration of Solanum anomalum fruit extract significantly reversed most of these biomarkers.  Histopathology of the kidneys also points to the mitigating effect of Solanum anomalum fruit against paracetamol-induced nephrotoxicity.

Paracetamol (acetaminophen) kidney Solanum anomalum nephrotoxicity rat

References (27)

  1. 1 Prevalence of Chronic Kidney Disease in the United States [DOI]
  2. 2 Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches [DOI]
  3. 3 Acetaminophen-induced nephrotoxicity: Pathophysiology, clinical manifestations, and management [DOI]
  4. 4 Management of paracetamol poisoning [DOI]
  5. 5 The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage [DOI]
  6. 6 Chrysin Protects Rat Kidney from Paracetamol-Induced Oxidative Stress, Inflammation, Apoptosis, and Autophagy: A Multi-Biomarker Approach [DOI]
  7. 7 Use of N-acetylcysteine in clinical toxicology [DOI]
  8. 8 Oxidative stress, mitochondrial permeability transition, and cell death in Cu-exposed trout hepatocytes [DOI]
  9. 9 Taurine protects rat testes against doxorubicin-induced oxidative stress as well as p53, Fas and caspase 12-mediated apoptosis [DOI]
  10. 10 Protective effect of arabic gum against acetaminophen-induced hepatotoxicity in mice [DOI]
  11. 11 Acetaminophen‐Related Acute Renal Failure without Fulminant Liver Failure [DOI]
  12. 12 Is erythropoietin a survival factor for red blood cells? [DOI]
  13. 13 Acetaminophen: Acute and chronic effects on renal function [DOI]
  14. 14 Method for Obtaining Venous Blood from the Orbital Sinus of the Rat or Mouse [DOI]
  15. 15 Nephrotoxicity After Acute Severe Acetaminophen Poisoning in Adolescents [DOI]
  16. 16 Quercetin protects against acetaminophen-induced hepatorenal toxicity by reducing reactive oxygen and nitrogen species [DOI]
  17. 17 Nephroprotective activity of Annona Squamosa leaves against paracetamol-induced nephrotoxicity in rats: in vitro and in vivo experiments [DOI]
  18. 18 Oral N-acetyl-l-cysteine is a safe and effective precursor of cysteine1 [DOI]
  19. 19 Therapeutic Efficacy of Rosa damascena Mill. on Acetaminophen-Induced Oxidative Stress in Albino Rats [DOI]
  20. 20 Improvement of Lead Acetate-Induced Testicular Injury and Sperm Quality Deterioration by Solanum Anomalum Thonn. Ex. Schumach Fruit Extracts in Albino Rats [DOI]
  21. 21 Co-administration of fresh grape fruit juice (GFJ) and bergamottin prevented paracetamol induced hepatotoxicity after paracetamol overdose in rats [DOI]
  22. 22 Phytochemical screening, and assessment of ameliorating effect of aqueous and ethanolic extracts of Gmelina arborea on drug induced hepatic and renal insufficiency in rats.
  23. 23 Nano ubiquinone: Promising candidate for treatment of renal toxicity induced by over dose of paracetamol [DOI]
  24. 24 Acetaminophen Induces Alterations to the Renal Tubular Ultrastructure in a Rat Model of Acute Nephrotoxicity Protected by Resveratrol and Quercetin [DOI]
  25. 25 HEPATO-RENAL EFFECT OF Solanum anomalum Thonn. Ex. Schumach FRUIT EXTRACTS ON LEAD-EXPOSED ALBINO RATS [DOI]
  26. 26 The effect of Paracetamol exposure on hepatic and renal tissues during statin usage [DOI]
  27. 27 The modulatory effect of Moringa oleifera leaf extract on endogenous antioxidant systems and inflammatory markers in acetaminophen-induced nephrotoxic mice model [DOI]

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