Effects of Various Concentrations of Quail Egg Solution on Glycemia and Antioxidant Parameters of Alloxan-induced Diabetic Rats

Abstract

This study evaluated the effects of different concentrations of quail egg solution on glycemia and some antioxidant markers in alloxan-induced diabetic rats. Thirty adult male albino rats were assigned to 5 groups of 6 rats per group. Groups 2, 3, 4 and 5 were made diabetic by single intraperitoneal injection of 160 mg/kg alloxan monohydrate. Upon establishment of diabetes (fasting blood glucose levels above 126 mg/dl), the rats in groups 2, 3 and 4 were respectively administered with 30, 15 and 7.5 mg/ml orally daily for 21 days. Groups 1 and 5 were administered with distillled water. Fasting blood glucose (FBG) levels of the rats were assessed 1 h, 6 h, 24 h and 21 days post treatment. On the 21st day, blood samples were collected for malondialdehyde (MDA), superoxide dismutase (SOD), and reduced glutathione (RSH) assays. Results indicate that administration of quail egg solution at the concentration of 30 mg/ml to the diabetic rats significantly (p< 0.05) reduced the FBG from 343.80 to 87.20 mg/dl on day 21 post treatment. There was significant (p< 0.05) reduction in the mean MDA values of the 30 mg/ml-treated groups compared to the negative control group. The SOD activity and glutathione levels of 30 mg/ml-treated diabetic rats were significantly (p< 0.05) higher compared to that of the diabetic untreated group. It was concluded that administration of quail egg solution especially at the concentration of 30 mg/ml to the diabetic rats resulted in hypoglycemia and improvement in the levels and activities of in vivo antioxidant parameters.