Safety Evaluation of Giant African Land Snails (Archachatina maginata) Haemolymph on Hematological and Biochemical Parameters of Albino Rats
L. Bashir, O. K. Shittu, M. B. Busari, S. Sani, M. I. Aisha
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 122–130 · Published 8 May 2015
10.9734/JAMPS/2015/16393Abstract
The safety of Archachatina maginata haemolymph on biochemical and hematological indices of albino rats was investigated. Twelve white albino rats were grouped into 3 (A-C) of 4 animals each. Group A rats serve as control groups and received no treatment, while groups B and C received 2 and 4 ml/kg of the haemolymph respectively, for ten days. Haemolymph administration resulted in a significant increase in the serum activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), alanine aminotransferase (ALT), total protein, albumin, total bilirubin and creatinine but significant decrease in the level of urea and chloride than the control rats. While serum bicarbonate, sodium, potassium, body weight gain, Relative organ weight were not significantly altered. However, there was a significant decrease in the relative kidney weight when compared with the control values. Haemolymph also produce significant dose dependent changes in erythrocyte, leucocyte and platelet indices when compared with control values. However, clinical observations for toxicological studies shows that the haemolymph did not produce any grossly negative behavioral changes, but increase water consumption was observed during the experimental periods. The results indicated changes in the investigated hematological and some biochemical parameters showing a more pronounced effect on the liver function than the renal function tests and at a higher dose than the lower dose. Hence, caution should be taken when using the haemolymph of Archachatina maginata for therapeutic purpose because it may also have some liver or tissue membrane damaging effect.
Cited by 20
Rofiyat Omolara Raji, Hadiza Lami Muhammad, Abdulkadir Abubakar · Clinical Phytoscience · 2021
Muhammad Ndako, Ali Audu Jigam, Adamu Yusuf Kabiru · Phytomedicine Plus · 2021
Adenike R. Alawode, Ahmed Y. Iyaka, Muhammed M. Ndamitso · Advanced Research in Life Sciences · 2020
Abdulhakeem Rotimi Agboola, Ako Hogan Itam, Chinedum Martins Ekeleme · Clinical Phytoscience · 2025
Farouk A. Oladoja, Emmanuel S. Irokosu, Marcus D. Ayoola · Clinical Complementary Medicine and Pharmacology · 2023
Sodiq Balogun, Abdulhakeem Rotimi Agboola, Rofiyat Omolara Raji · AROC in Natural Products Research · 2025
Laila Mowafy, Manal Abdul-Hamid, Nadia Moustafa · Pesticide Biochemistry and Physiology · 2024
Murtala Akanji Abdullahi, Elijah Oladapo Oyinloye, Akinyinka Alabi · Drug Metabolism and Personalized Therapy · 2022
Laila Mowafy, Manal Abdul‐Hamid, Heba Abdel‐Tawab · Annals of Applied Biology · 2025
Research Unit, Forestry Research Institute of Nigeria-Southern Guinea Research Station, Mokwa, Nigeria., Adenike R. Alawode, Muhammed Dauda · Iranian Journal of Toxicology · 2020
Related research
- Effects of Hydro-ethanolic Leaf Extract of Tithonia diversifolia on Parasitaemia Level, Serum Metabolites and Histopathology of Organs in Swiss Albino Mice Infected with Plasmodium berghei NK65 — shares topic coverage
- Common Findings in Ultrasound Examination of the Liver and Kidney in Sokoto Metropolis — shares topic coverage
- Liver Profile of Artemether-lumefantrine-tinidazole in Healthy and Parasitized Mice — shares topic coverage
- Sonographic Assessment of Maternal Portal Vein Diameter in Healthy Pregnancy in South-South Nigeria — shares topic coverage
- Quadruple Arterial Blood Supply to the Liver: A Rare Variation — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
20
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.