Clinical, Therapeutic, and Evolutionary Aspects of Stevens-Johnson Syndrome and Lyell's Syndrome in the Pediatric Department of the University Hospital Center of Libreville: Report of Two Clinical Cases

Abstract

Objective: The objective of this study is to report two pediatric cases of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), highlighting the clinical, therapeutic, and evolutionary aspects of these conditions. Study Design: This is a case study conducted at the University Hospital Center of Libreville in Gabon, involving two children aged 3 and 5 years, diagnosed with SJS and TEN, respectively. The cases were observed and followed over several weeks, with the collection of clinical, biological, and evolutionary data for each patient. Methodology:  Both children developed symptoms after taking medications, including antibiotics and anti-inflammatory drugs. Data were collected through clinical examinations, laboratory tests, and radiographs. Management included intensive care, antibiotic therapy, corticosteroids, local care, and electrolyte supplementation. Results: Both cases showed progressive improvement of symptoms, including a reduction in skin lesions and normalization of electrolytes. However, sequelae such as keratoconjunctivitis and liver dysfunction persisted, although the patients were discharged with favorable outcomes after intensive follow-up. Conclusion: These cases underscore the importance of early recognition and a multidisciplinary approach in the management of SJS and TEN. Despite the challenges in resource-limited settings, appropriate management can significantly improve outcomes. Early intervention and rigorous follow-up are crucial to minimize complications and promote healing.