A Subset of Genes Can Distinguish between Bortezomib Responsive Versus Bortezomib Resistant Myeloma

References (49)

1. 1 XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor [DOI]
2. 2 XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response [DOI]
3. 3 Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response [DOI]
4. 4 ER stress-induced cell death mechanisms [DOI]
5. 5 Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State [DOI]
6. 6 Plasma cell differentiation requires the transcription factor XBP-1 [DOI]
7. 7 Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells [DOI]
8. 8 NF-κB as a Therapeutic Target in Multiple Myeloma [DOI]
9. 9 Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1 [DOI]
10. 10 Molecular sequelae of proteasome inhibition in human multiple myeloma cells [DOI]
11. 11 Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis [DOI]
12. 12 Role of the unfolded protein response in cell death [DOI]
13. 13 Proteasome-dependent endoplasmic reticulum-associated protein degradation: An unconventional route to a familiar fate [DOI]
14. 14 Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. [DOI]
15. 15 Proteasome Inhibitor PS-341 Induces Apoptosis through Induction of Endoplasmic Reticulum Stress-Reactive Oxygen Species in Head and Neck Squamous Cell Carcinoma Cells [DOI]
16. 16 Gene expression profiling and correlation with outcome in clinical trials of the proteasome inhibitor bortezomib [DOI]
17. 17 Extensive Immunoglobulin Production Sensitizes Myeloma Cells for Proteasome Inhibition [DOI]
18. 18 Xbp1s-Negative Tumor B Cells and Pre-Plasmablasts Mediate Therapeutic Proteasome Inhibitor Resistance in Multiple Myeloma [DOI]
19. 19 Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells [DOI]
20. 20 Bortezomib Sensitizes Pancreatic Cancer Cells to Endoplasmic Reticulum Stress-Mediated Apoptosis [DOI]
21. 21 Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells [DOI]
22. 22 The X‐box binding protein‐1 transcription factor is required for plasma cell differentiation and the unfolded protein response [DOI]
23. 23 Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells [DOI]
24. 24 Differential Regulation of Noxa in Normal Melanocytes and Melanoma Cells by Proteasome Inhibition: Therapeutic Implications [DOI]
25. 25 Mitochondrial-Mediated Disregulation of Ca2+ Is a Critical Determinant of Velcade (PS-341/Bortezomib) Cytotoxicity in Myeloma Cell Lines [DOI]
26. 26 Bortezomib-resistant myeloma cell lines: a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress [DOI]
27. 27 Impaired bortezomib binding to mutant β5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells [DOI]
28. 28 The resistance mechanisms of proteasome inhibitor bortezomib [DOI]
29. 29 The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound with a Membrane-Binding Domain and a p97/VCP Inhibitory Group [DOI]
30. 30 Using transcriptome sequencing to identify mechanisms of drug action and resistance [DOI]
31. 31 The hierarchical relationship between MAPK signaling and ROS generation in human leukemia cells undergoing apoptosis in response to the proteasome inhibitor Bortezomib [DOI]
32. 32 Bortezomib/proteasome inhibitor triggers both apoptosis and autophagy-dependent pathways in melanoma cells [DOI]
33. 33 Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells [DOI]
34. 34 Advances in the understanding of mechanisms and therapeutic use of bortezomib.
35. 35 The Hsp90 inhibitor IPI-504 overcomes bortezomib resistance in mantle cell lymphoma in vitro and in vivo by down-regulation of the prosurvival ER chaperone BiP/Grp78 [DOI]
36. 36 Activation of ATF4 mediates unwanted Mcl-1 accumulation by proteasome inhibition [DOI]
37. 37 Molecular Mechanisms of Bortezomib Resistant Adenocarcinoma Cells [DOI]
38. 38 Biologic sequelae of nuclear factor–κB blockade in multiple myeloma: therapeutic applications [DOI]
39. 39 Profiling Bortezomib Resistance Identifies Secondary Therapies in a Mouse Myeloma Model [DOI]
40. 40 Macrophage Metalloelastase (MMP12) Regulates Adipose Tissue Expansion, Insulin Sensitivity, and Expression of Inducible Nitric Oxide Synthase [DOI]
41. 41 Targeting HSP 90 Induces Apoptosis and Inhibits Critical Survival and Proliferation Pathways in Multiple Myeloma [DOI]
42. 42 Tissue distribution and depletion kinetics of bortezomib and bortezomib-related radioactivity in male rats after single and repeated intravenous injection of 14C-bortezomib [DOI]
43. 43 Combined Inhibition of p97 and the Proteasome Causes Lethal Disruption of the Secretory Apparatus in Multiple Myeloma Cells [DOI]
44. 44 In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB [DOI]
45. 45 Understanding the Biology of CRLF2-Overexpressing Acute Lymphoblastic Leukemia [DOI]
46. 46 The proliferation arrest of primary tumor cells out-of-niche is associated with widespread downregulation of mitotic and transcriptional genes [DOI]
47. 47 Niche-modulated and niche-modulating genes in bone marrow cells [DOI]
48. 48 Cutting Edge: Proteasome Involvement in the Degradation of Unassembled Ig Light Chains [DOI]
49. 49 Ubiquitination and Degradation of the Inhibitors of NF- B [DOI]

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