A Review on Resealed Erythrocytes as a Novel Drug Delivery System
Karra Geetha, Deshapaka Pravalika, R Shireesh Kiran, Simmu, Thatikonda Rajitha
Asian Journal of Medicine and Health · pp. 188–197 · Published 14 May 2024
10.9734/ajmah/2024/v22i61036Abstract
The most prevalent form of blood cell is the red blood cell. RBCs resemble biconcave discs with a 7.8 mm diameter and a thickness of about 2.2 mm. There are two ways that erythrocytes can be used as carriers: Targeting a specific tissue or organ, for continuous or extended medication release. For the delivery of medications, various kinds of mammalian erythrocytes have been employed. There are numerous techniques, including the hypo-osmotic method, the dilution method, the dialysis method, the press well method, the isotonic osmotic lyses, the electrical breakdown method, the endocytosis method, the membrane perturbation method, the normal transport method, and the lipid fusion method. After erythrocytes have been loaded with the therapeutic drug, carrier cells are subjected to physical, cellular, and biological examinations. Several invitro tests have shown the value of carrier RBCs. The RBC mediated microinjection that occurs most frequently invitro. Today, a wide range of uses for resealed erythrocytes as medication carriers, enzyme replacement treatment, etc. have been proposed.
References (20)
- 1 Targeted and Controlled Drug Delivery: Novel Carrier Systems [DOI]
- 2 Biological Membranes Architecture and Function [DOI]
- 3 Drug, enzyme and peptide delivery using erythrocytes as carriers [DOI]
- 4 Applications of carrier erythrocytes in delivery of biopharmaceuticals [DOI]
- 5 Intra-Erythrocyte Infusion of Dexamethasone Reduces Neurological Symptoms in Ataxia Teleangiectasia Patients: Results of a Phase 2 Trial [DOI]
- 6 Erythrocyte‐mediated delivery of dexamethasone in patients with chronic obstructive pulmonary disease [DOI]
- 7 Positive effect of erythrocyte-delivered dexamethasone in ataxia-telangiectasia [DOI]
- 8 In Vitro Characterization of Human Intact Erythrocytes Loaded by Enalaprilat [DOI]
- 9 Dexamethasone Partially Rescues Ataxia Telangiectasia-mutated (ATM) Deficiency in Ataxia Telangiectasia by Promoting a Shortened Protein Variant Retaining Kinase Activity [DOI]
- 10 Long‐term Treatment With Autologous Red Blood Cells Loaded With Dexamethasone 21–Phosphate in Pediatric Patients Affected by Steroid‐dependent Crohn Disease [DOI]
- 11 Therapeutic efficacy of asparaginase encapsulated in intact erythrocytes [DOI]
- 12 In vivo clearance of antibody-sensitized human drug carrier erythrocytes [DOI]
- 13 Survival of sucrose-loaded erythrocytes in the circulation [DOI]
- 14 Efficacy of homologous inositol hexaphosphate‐loaded red blood cells in sickle transgenic mice [DOI]
- 15 Niosomes: A Promising Novel Nano Carrier for Drug Delivery [DOI]
- 16 Resealed Erythrocytes As Carriers For Salbutamol Sulphate
- 17 Entry of Ferritin into Human Red Cells during Hypotonic Haemolysis [DOI]
- 18 Antagonism of cyanide intoxication with murine carrier erythrocytes containing bovine rhodanese and sodium thiosulfate [DOI]
- 19 Low doses of dexamethasone constantly delivered by autologous erythrocytes slow the progression of lung disease in cystic fibrosis patients [DOI]
- 20 Digitalis purpurea Improve Obesity Inducing Alternation of Cardiac Infarction: A Meta Analysis [DOI]
Cited by 3
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