Skip to content
Research Article Open access CC BY 4.0

A Review on Pharmacological and Therapeutic Potential of Aloe barbadensis Miller

Deepak Sharma, Naimish Purohit, Shiwa Chaubey, Mohan Tiwari, Mradu Bhadauriya, . Mohit, Nilam Bhasker, Dharmendra Kumar

European Journal of Medicinal Plants · pp. 23–43 · Published 28 May 2022

10.9734/ejmp/2022/v33i630471

Abstract

Aloe vera, a popular succulent perennial medicinal plant with a wide range of phytochemicals that have shown various pharmacological activities including anti-oxidant, antimicrobial, antidiabetic, wound healing promotion and so on. Acemannan, aloe-emodin, aloin, aloesin, and emodin are widely investigated active constituents that show various pharmacological activities. Thus, the purpose of this review is to highlight previous pharmacological studied conducted in vivo, in vitro and human assays over the past decades. As current pharmacological research is focused on anticancer and neurological action, it would be interesting and important to study the main compounds present in Aloe vera for therapeutic purposes.

Aloe vera anti-oxidant acemannan aloe-emodin emodin.

References (89)

  1. 1 Studies in Natural Products Chemistry [DOI]
  2. 2 Effect of Extraction Solvent/Technique on the Antioxidant Activity of Selected Medicinal Plant Extracts [DOI]
  3. 3 Composition and Applications of Aloe vera Leaf Gel [DOI]
  4. 4 Aloe vera: A short review [DOI]
  5. 5 Aloe vera leaf gel: a review update [DOI]
  6. 6 The Aloe vera phenomenon: A review of the properties and modern uses of the leaf parenchyma gel [DOI]
  7. 7 Aloe vera: a systematic review of its clinical effectiveness.
  8. 8 Free radicals, antioxidant defense systems, and schizophrenia [DOI]
  9. 9 Compositional features of polysaccharides from Aloe vera (Aloe barbadensis Miller) plant tissues [DOI]
  10. 10 Anti-inflammatory and wound healing activity of a growth substance in Aloe vera [DOI]
  11. 11 Antibacterial activities and antioxidant capacity of Aloe vera [DOI]
  12. 12 Identification of Five Phytosterols from Aloe Vera Gel as Anti-diabetic Compounds [DOI]
  13. 13 Chemistry of Aloe Species [DOI]
  14. 14 Influence of Aloe vera on the glycosaminoglycans in the matrix of healing dermal wounds in rats [DOI]
  15. 15 Isolation, Purification and Evaluation of Antibacterial Agents from Aloe vera [DOI]
  16. 16 Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus [DOI]
  17. 17 Acemannan Stimulates Gingival Fibroblast Proliferation; Expressions of Keratinocyte Growth Factor-1, Vascular Endothelial Growth Factor, and Type I Collagen; and Wound Healing [DOI]
  18. 18 Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages [DOI]
  19. 19 Phenolic Constituents, Antioxidant and Preliminary Antimycoplasmic Activities of Leaf Skin and Flowers of Aloe vera (L.) Burm. f. (syn. A. barbadensis Mill.) from the Canary Islands (Spain) [DOI]
  20. 20 Oral Ingestion of Aloe vera Phytosterols Alters Hepatic Gene Expression Profiles and Ameliorates Obesity-Associated Metabolic Disorders in Zucker Diabetic Fatty Rats [DOI]
  21. 21 Anti-Inflammatory and Antiarthritic Activity of Anthraquinone Derivatives in Rodents [DOI]
  22. 22 Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells [DOI]
  23. 23 Differential cellular localization of antioxidant enzymes in the trigeminal ganglion [DOI]
  24. 24 Isolation and characterization of novel protein with anti-fungal and anti-inflammatory properties from Aloe vera leaf gel [DOI]
  25. 25 Isolation and identification of a phenolic antioxidant from Aloe barbadensis [DOI]
  26. 26 The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas [DOI]
  27. 27 Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo [DOI]
  28. 28 The Effect of Aloe Vera Oral Administration on Cutaneous Wound Healing in Type 2 Diabetic Rats [DOI]
  29. 29 Extraction and purification of anthraquinones derivatives from Aloe vera L. using alcohol/salt aqueous two-phase system [DOI]
  30. 30 Inhibitory Mechanism of Aloe Single Component (Alprogen) on Mediator Release in Guinea Pig Lung Mast Cells Activated with Specific Antigen-Antibody Reactions [DOI]
  31. 31 Attenuation of Biochemical Parameters in Streptozotocin-induced Diabetic Rats by Oral Administration of Extracts and Fractions of Cephalotaxus sinensis. [DOI]
  32. 32 Effect of Aloe vera gel extract on antioxidant enzymes and azoxymethane-induced oxidative stress in rats.
  33. 33 Bioactive Compounds and Medicinal Properties of Aloe Vera L.: An Update [DOI]
  34. 34 Anti-inflammatory effects of Aloe vera on leukocyte-endothelium interaction in the gastric microcirculation of Helicobacter pylori-infected rats.
  35. 35 Chemopreventive effects of aloin against 1,2-dimethylhydrazine-induced preneoplastic lesions in the colon of Wistar rats [DOI]
  36. 36 Evaluation of radioprotective efficacy and possible mechanism of action of Aloe gel [DOI]
  37. 37 Comparative evaluation of antimicrobial activity of hydroalcoholic extract of Aloe vera, garlic, and 5% sodium hypochlorite as root canal irrigants against Enterococcus faecalis: An in vitro study [DOI]
  38. 38 Five chromones from Aloe Vera leaves [DOI]
  39. 39 Dietary Aloe Improves Insulin Sensitivity via the Suppression of Obesity-induced Inflammation in Obese Mice [DOI]
  40. 40 Augmented humoral immune response and decreased cell-mediated immunity by Aloe vera in rats [DOI]
  41. 41 Natural phosphodiesterase-4 inhibitors from the leaf skin of Aloe barbadensis Miller [DOI]
  42. 42 Peroxidase Activity in Aloe barbadensis Commercial Gel: Probable Role in Skin Protection [DOI]
  43. 43 Aloin: A natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities [DOI]
  44. 44 A new triglucosylated naphthalene glycoside from Aloe vera L. [DOI]
  45. 45 Aloenin B, a New Diglucosylated 6-Phenyl-2-pyrone from Kenya Aloe [DOI]
  46. 46 Three chromones of Aloe vera leaves [DOI]
  47. 47 A pilot randomized placebo controlled trial of 2 Aloe vera supplements in patients with pre-diabetes/metabolic syndrome [DOI]
  48. 48 Differential cellular localization of antioxidant enzymes in the trigeminal ganglion [DOI]
  49. 49 Medicinal Plants: Their Use in Anticancer Treatment. [DOI]
  50. 50 In Vivo Evalution of Hypoglycemic Activity of Aloe spp. and Identification of Its Mode of Action on GLUT-4 Gene Expression In Vitro [DOI]
  51. 51 Oxidative Stress: Harms and Benefits for Human Health [DOI]
  52. 52 Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources [DOI]
  53. 53 Pharmacological Update Properties of Aloe Vera and its Major Active Constituents [DOI]
  54. 54 Aloe vera (L.) Webb.: Natural Sources of Antioxidants – A Review [DOI]
  55. 55 Effect of climate change on phytochemical diversity, total phenolic content and in vitro antioxidant activity of Aloe vera (L.) Burm.f. [DOI]
  56. 56 The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review. [DOI]
  57. 57 Aloe-emodin inhibits Staphylococcus aureus biofilms and extracellular protein production at the initial adhesion stage of biofilm development [DOI]
  58. 58 Aloesin from Aloe vera accelerates skin wound healing by modulating MAPK/Rho and Smad signaling pathways in vitro and in vivo [DOI]
  59. 59 Identification of potential inhibitors of SARS-CoV-2 main protease from Aloe vera compounds: A molecular docking study [DOI]
  60. 60 The Effects of Aloe vera on Wound Healing in Cell Proliferation, Migration, and Viability.
  61. 61 Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells [DOI]
  62. 62 Chemical Constituents, Antimicrobial Activity, and Food Preservative Characteristics of Aloe vera Gel [DOI]
  63. 63 Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review [DOI]
  64. 64 Aloe vera Inhibits Proliferation of Human Breast and Cervical Cancer Cells and Acts Synergistically with Cisplatin [DOI]
  65. 65 Assessment of Anti HSV-1 Activity of Aloe Vera Gel Extract: an In Vitro Study.
  66. 66 In vitro evaluation of anthraquinones from Aloe vera (Aloe barbadensis Miller) roots and several derivatives against strains of influenza virus [DOI]
  67. 67 Aloe vera gel homogenate shows anti-inflammatory activity through lysosomal membrane stabilization and downregulation of TNF-α and Cox-2 gene expressions in inflammatory arthritic animals [DOI]
  68. 68 Chemical Investigation of Major Constituents in Aloe vera Leaves and Several Commercial Aloe Juice Powders [DOI]
  69. 69 Beta-Sitosterol: As Immunostimulant, Antioxidant and Inhibitor of SARS-CoV-2 Spike Glycoprotein [DOI]
  70. 70 Aloe vera gel extract: Safety evaluation for acute and chronic oral administration in Sprague-Dawley rats and anticancer activity in breast and lung cancer cells [DOI]
  71. 71 Mass Spectrometry-Based Metabolite Profiling and Antioxidant Activity of Aloe vera (Aloe barbadensis Miller) in Different Growth Stages [DOI]
  72. 72 Aloe Polysaccharides Inhibit Influenza A Virus Infection—A Promising Natural Anti-flu Drug [DOI]
  73. 73 Aloe Metabolites Prevent LPS-Induced Sepsis and Inflammatory Response by Inhibiting Mitogen-Activated Protein Kinase Activation [DOI]
  74. 74 Analysis of phytochemical constituents, antibacterial, antioxidant, photoprotective activities and cytotoxic effect of leaves extracts and fractions of Aloe vera [DOI]
  75. 75 Barbaloin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK [DOI]
  76. 76 ALOE VERA: A VALUABLE WONDER PLANT FOR FOOD, MEDICINE AND COSMETIC USE - A REVIEW
  77. 77 Traditional plants with antioxidant properties in clinical trials—A systematic review [DOI]
  78. 78 DNA degradation by aqueous extract of Aloe vera in the presence of copper ions.
  79. 79 Induction of Mitotic Catastrophe in Human Cervical Cancer Cells After Administration of Aloe-emodin [DOI]
  80. 80 A Pharmacoeconomic Focus on Medicinal Plants with Anticancer Activity [DOI]
  81. 81 Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways [DOI]
  82. 82 Effects of Six Weeks Endurance Training and Aloe Vera Supplementation on COX-2 and VEGF Levels in Mice with Breast Cancer [DOI]
  83. 83 Aloe vera extract: A novel antimicrobial and antibiofilm against methicillin resistant Staphylococcus aureus strains [DOI]
  84. 84 The potential benefits of using aloe vera in stoma patient skin care [DOI]
  85. 85 Arid horticultural crops: Status and opportunities under changing climatic conditions [DOI]
  86. 86 A Comprehensive Study of the Neuropharmacological Profile of Methanol Leaf Extract of Aloe vera and Identification of Associated Neuroprotective Compounds through Gas chromatography-mass spectrometry Analysis [DOI]
  87. 87 Anti-Inflammatory Agents [DOI]
  88. 88 Neuroprotective Effects of Pine Bark and Aloe vera on the Locomotor Activity in Focal Cerebral Ischemia: Possible Antioxidant Mechanisms [DOI]
  89. 89 International Journal of Trend in Scientific Research and Development [DOI]

Cited by 15

Ornamental Vascular Plant Diversity in Basilicata (Southern Italy)

Emilio Di Gristina, Raimondo Pardi, Fortunato Cirlincione · Plants · 2025

Herbs in Traditional Medicine: The Roots of Healing

Sonam Pandey, Deepika Mathur · Herb-Drug Interactions: A Medicinal Approach · 2025

The Anticancer Potential of Van Lake Basin Plants

Gül Görmez · Yüzüncü Yıl Üniversitesi Fen Bilimleri Enstitüsü Dergisi · 2024

A critical review on phytochemicals as antiviral medications for SARS-CoV-2 virus infection

Manoja Das, Namita Panigrahy · Naunyn-Schmiedeberg's Archives of Pharmacology · 2024

Showing 5 of 15 known citations — external sources report more than can currently be individually listed.

Article metrics

Real usage data collected on this platform.

54

Page views

0

PDF downloads

22

Outbound clicks

15

Citations

Views over time

Views by country

Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".

Traffic sources

Referring site, by host.

Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.