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Research Article Open access CC BY 4.0

A Review on Human Metapneumovirus and Human Bocavirus Associated with Acute Respiratory Tract Infections

Harikrishnan Narayanan, Balaji Nandagopal, Mageshbabu Ramamurthy, Kumaran Vadivel

Asian Journal of Research in Infectious Diseases · pp. 37–51 · Published 1 Mar 2023

10.9734/ajrid/2023/v12i3247

Abstract

One of the significant causes of morbidity and mortality among young children in developing nations is acute respiratory tract infections (ARTIs). It is also highly contagious, widely prevalent, and transmissible from person to person. It risks young children, the elderly, and those with immune system disorders. Acute respiratory infections are thought to cause 2.6 million child deaths annually worldwide, according to the World Health Organization (WHO) [1]. Infections in children with human metapneumovirus (hMPV) and bocavirus (HBoV) are linked to a high prevalence of ARTIs. It has been determined that hMPV is the second-leading cause of infant bronchiolitis, after the respiratory syncytial virus (RSV), of upper and lower respiratory tract infections. Although HBoV was first discovered in children's airways, the high detection rates of other viral pathogens and the discovery of HBoV in stool raise doubts about the virus's significance in respiratory tract infections. According to the published literature, only a few studies have identified ARTIs or demonstrated the importance of early diagnosis and treatment of ARTIs. This review article aims to thoroughly explain the aetiology, epidemiology, clinical characteristics, diagnostic approaches, and management of hMPV and HBoV.

Communicable diseases emerging human metapneumovirus human bocavirus acute respiratory tract infections

References (88)

  1. 1 Respiratory Syncytial Virus: Infection, Detection, and New Options for Prevention and Treatment [DOI]
  2. 2 Recent advances in the detection of respiratory virus infection in humans [DOI]
  3. 3 ICTV Virus Taxonomy Profile: Parvoviridae [DOI]
  4. 4 Practical Guidance for Clinical Microbiology Laboratories: Viruses Causing Acute Respiratory Tract Infections [DOI]
  5. 5 Increased Detection of Viruses in Children with Respiratory Tract Infection Using PCR [DOI]
  6. 6 Promotion of virus assembly and organization by the measles virus matrix protein [DOI]
  7. 7 Human bocaviruses and paediatric infections [DOI]
  8. 8 Point-of-care diagnostics for respiratory viral infections [DOI]
  9. 9 Comparing Human Metapneumovirus and Respiratory Syncytial Virus: Viral Co-Detections, Genotypes and Risk Factors for Severe Disease [DOI]
  10. 10 A review on epidemiology and impact of human metapneumovirus infections in children using TIAB search strategy on PubMed and PubMed Central articles [DOI]
  11. 11 Advances in laboratory assays for detecting human metapneumovirus [DOI]
  12. 12 Respiratory virus infections [DOI]
  13. 13 Human bocavirus in children hospitalized for acute respiratory tract infection in Rome [DOI]
  14. 14 Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients [DOI]
  15. 15 Viral and Bacterial Etiologies of Acute Respiratory Infections Among Children Under 5 Years in Senegal [DOI]
  16. 16 Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey [DOI]
  17. 17 Comparison of viral and epidemiological profiles of hospitalized children with severe acute respiratory infection in Beijing and Shanghai, China [DOI]
  18. 18 Clinical Impact of Rapid Point-of-Care PCR Influenza Testing in an Urgent Care Setting: a Single-Center Study [DOI]
  19. 19 Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma [DOI]
  20. 20 Human Bocavirus infection and respiratory tract disease identified in a UK patient cohort [DOI]
  21. 21 Comparative Diagnosis of Human Bocavirus 1 Respiratory Infection With Messenger RNA Reverse-Transcription Polymerase Chain Reaction (PCR), DNA Quantitative PCR, and Serology [DOI]
  22. 22 Determinants of acute respiratory infections among under five children in a rural area of Tamil Nadu, India [DOI]
  23. 23 A multiplex one-tube nested real time RT-PCR assay for simultaneous detection of respiratory syncytial virus, human rhinovirus and human metapneumovirus [DOI]
  24. 24 A Potent Neutralizing Site III-Specific Human Antibody Neutralizes Human Metapneumovirus In Vivo [DOI]
  25. 25 Typical Bacterial Pneumonia
  26. 26 Interferon-Mediated Response to Human Metapneumovirus Infection [DOI]
  27. 27 Simultaneous detection of respiratory syncytial virus and human metapneumovirus by one-step multiplex real-time RT-PCR in patients with respiratory symptoms [DOI]
  28. 28 Molecular epidemiology and clinical severity of Human Bocavirus (HBoV) 1–4 in children with acute gastroenteritis from Pune, Western India [DOI]
  29. 29 Rapid antigen detection test for respiratory syncytial virus diagnosis as a diagnostic tool [DOI]
  30. 30 Epidemiological, clinical and genotypic features of human Metapneumovirus in patients with influenza-like illness in Senegal, 2012 to 2016 [DOI]
  31. 31 Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized [DOI]
  32. 32 Human bocavirus (HBoV) in Kuwait: molecular epidemiology and clinical outcome of the virus among patients with respiratory diseases [DOI]
  33. 33 Outcomes of severe human metapneumovirus-associated community-acquired pneumonia in adults [DOI]
  34. 34 Outbreak of Human Metapneumovirus in a Nursing Home: A Clinical Perspective [DOI]
  35. 35 Viral etiologies and epidemiology of patients with acute respiratory infections based on sentinel hospitals in Gansu Province, Northwest China, 2011‐2015 [DOI]
  36. 36 Cell Culture, Cytopathic Effect and Immunofluorescence Diagnosis of Viral Infection [DOI]
  37. 37 Human bocavirus in hospitalized children under 5 years with acute respiratory infection, São Paulo, Brazil, 2010 [DOI]
  38. 38 The role of human Metapneumovirus genetic diversity and nasopharyngeal viral load on symptom severity in adults [DOI]
  39. 39 Evaluation of monoclonal antibodies that detect conserved proteins from Respiratory Syncytial Virus, Metapneumovirus and Adenovirus in human samples [DOI]
  40. 40 What is the role of rapid molecular testing for seniors and other at-risk adults with respiratory syncytial virus infections? [DOI]
  41. 41 Genetic Diversity and Phylogenetic Analysis of Human Bocavirus 2 in Pediatric Patients with Acute Gastroenteritis in Taiwan [DOI]
  42. 42 Phylogenetic variability of Human Metapneumovirus in patients with acute respiratory infections in Cameroon, 2011–2014 [DOI]
  43. 43 Human bocavirus is detected in human placenta and aborted tissues [DOI]
  44. 44 Phylogenic analysis of human bocavirus detected in children with acute respiratory infection in Yaounde, Cameroon [DOI]
  45. 45 Molecular epidemiology of human bocavirus in children with acute gastroenteritis from North Region of Brazil [DOI]
  46. 46 Phylogenetic analysis of human bocavirus in children with acute respiratory infections in Iran [DOI]
  47. 47 Hospital admissions for lower respiratory tract infections after early‐, late‐, and post‐term birth [DOI]
  48. 48 Prevalence of Human Metapneumovirus Infections in Iran: A Systematic Review and Meta-Analysis [DOI]
  49. 49 Otopsi Olgularında Viral Solunum Yolu Enfeksiyonu Etkenlerinin Multipleks PCR Yöntemi ile Araştırılması: Beş Yıllık Bir Çalışma [DOI]
  50. 50 Human Metapneumovirus Infection [DOI]
  51. 51 A Feasibility Study Of Fricke Dosimetry As An Absorbed Dose To Water Standard For192ir Hdr Sources [DOI]
  52. 52 Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study [DOI]
  53. 53 Cell Cultures for Virology: Usability, Advantages, and Prospects [DOI]
  54. 54 Recent Molecular Evolution of Human Metapneumovirus (HMPV): Subdivision of HMPV A2b Strains [DOI]
  55. 55 Determinants of acute respiratory infection among under-five children in rural Ethiopia [DOI]
  56. 56 Zoonotic Origins of Human Metapneumovirus: A Journey from Birds to Humans [DOI]
  57. 57 Epidemiology and genotypic diversity of human metapneumovirus in paediatric patients with acute respiratory infection in Beijing, China [DOI]
  58. 58 Prevalence and factors associated with acute respiratory infection among under-five children in selected tertiary hospitals of Kathmandu Valley [DOI]
  59. 59 Human metapneumovirus in hospitalized children with acute respiratory tract infections in Beijing, China [DOI]
  60. 60 Structural basis for ultrapotent antibody-mediated neutralization of human metapneumovirus [DOI]
  61. 61 Detection and identification of potentially infectious gastrointestinal and respiratory viruses at workplaces of wastewater treatment plants with viability qPCR/RT-qPCR [DOI]
  62. 62 Clinical characteristics and molecular epidemiology of human metapneumovirus in children with acute lower respiratory tract infections in China, 2017 to 2019: A multicentre prospective observational study [DOI]
  63. 63 Prevalence of the Acute Respiratory Infections and Associated Factors in the Rural Areas and Urban Slum Areas of Western Maharashtra, India: A Community-Based Cross-Sectional Study [DOI]
  64. 64 Aetiology of childhood pneumonia in low- and middle-income countries in the era of vaccination: a systematic review [DOI]
  65. 65 Effect of smoke-free policies in outdoor areas and private places on children's tobacco smoke exposure and respiratory health: a systematic review and meta-analysis [DOI]
  66. 66 Epidemiologic and clinical characteristics of human bocavirus infection in infants and young children suffering with community acquired pneumonia in Ningxia, China [DOI]
  67. 67 Prevalence and Molecular Characterization of Human Bocavirus Detected in Croatian Children with Respiratory Infection [DOI]
  68. 68 Role of human metapneumovirus glycoprotein G in modulation of immune responses [DOI]
  69. 69 Risk Factors for Perioperative Respiratory Adverse Events in Children with Recent Upper Respiratory Tract Infection: A Single-Center-Based Retrospective Study [DOI]
  70. 70 Understanding the rural–urban disparity in acute respiratory infection symptoms among under-five children in Sub-Saharan Africa: a multivariate decomposition analysis [DOI]
  71. 71 Prevalence and Clinical Characterization of Bocavirus Infection in a Specialized Children's Hospital in Saudi Arabia [DOI]
  72. 72 Recent Advances in Early Diagnosis of Viruses Associated with Gastroenteritis by Biosensors [DOI]
  73. 73 Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review [DOI]
  74. 74 Contamination of Human Bocavirus Genotypes 1, 2, 3, and 4 in Environmental Waters in Thailand [DOI]
  75. 75 Human bocavirus-1 infections in Australian children aged < 2 years: a birth cohort study [DOI]
  76. 76 Viral and Atypical Bacterial Detection in Young Nepalese Children Hospitalized with Severe Pneumonia [DOI]
  77. 77 Human bocavirus genotypes 1, 2, and 3 circulating in pediatric patients with acute gastroenteritis in Chiang Mai, Thailand, 2012–2018 [DOI]
  78. 78 Respiratory viruses among pediatric inpatients with acute lower respiratory tract infections in Jinan, China, 2016–2019 [DOI]
  79. 79 Diagnosis and clinical significance of Human bocavirus 1 in children hospitalized for lower acute respiratory infection: molecular detection in respiratory secretions and serum [DOI]
  80. 80 Identification of biomarkers for disease severity in nasopharyngeal secretions of infants with upper or lower respiratory tract viral infections [DOI]
  81. 81 Molecular characterization and clinical impact of human bocavirus at a tertiary hospital in Barcelona (Catalonia, Spain) during the 2014–2017 seasons [DOI]
  82. 82 Evaluation of the ImmuView RSV Test for Rapid Detection of Respiratory Syncytial Virus in Adult Patients with Influenza-Like Symptoms [DOI]
  83. 83 Characteristics of patients with viral infections of the lower respiratory tract: A retrospective study [DOI]
  84. 84 Detection and phylogenetic analysis of Human bocavirus in children diagnosed with acute respiratory tract infection [DOI]
  85. 85 Prevalence and Genetic Characteristics of Human Bocaviruses Detected in Patients with Acute Respiratory Infections in Bulgaria [DOI]
  86. 86 Sociodemographic and environmental factors influencing acute respiratory infections among under-five children of chars (riverine islands) of Tinsukia District, Assam: A community-based cross-sectional study [DOI]
  87. 87 Yaşlı Kadınlarda Üreme Sağlığı
  88. 88 Children's immunity at risk [DOI]

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