Evaluation of CNS Depressant, Antidiarrheal and Antipyretic Activities of Ethanolic Leaf Extract of Calophyllum inophyllum L. on Swiss Albino Mice
Seuly Akter, Md. Saddam Hossain, Md. Rubel Mia, Md. Shahid Sarwar
Journal of Advances in Medical and Pharmaceutical Sciences · pp. 1–9 · Published 11 Mar 2017
10.9734/JAMPS/2017/29994Abstract
Objective: The main objective of the present study was to evaluate the CNS depressant, antidiarrheal and antipyretic activities of ethanolic leaf extract of Calophyllum inophyllum L. Methods: In the present study CNS depressant activity of C. inophyllum was carried out using hole-cross, hole-board and open-field models in swiss albino mice whereas castor-oil induced diarrhea was used to evaluate antidiarrheal activity. The antipyretic activity was conducted by Brewer’s yeast-induced hyperthermia in mice. Results: The experimental result indicates that the ethanolic extract of C. inophyllum induced CNS depression significantly (p<0.05) in tested animals and the observed effect was dose dependent comparable to standard drug diazepam. The plant extract at the dose of 250 and 500 mg/kg body weight showed significant inhibition of 41.66% and 62.19% in castor oil-induced diarrheal method. In yeast-induced pyrexia, the plant extract displayed dose-dependent inhibition as compared to paracetamol. Conclusion: This study concludes that C. inophyllum leaf has significant CNS depressant, antidiarrheal and antipyretic activities which provide scientific support for its medicinal applications.
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