Synchronous Granulosa Cell Tumor of the Ovary and Urothelial Carcinoma of the Urinary Bladder: A Rare Case Report

Abstract

The incidence of secondary primary malignancies (SPM) has been reported to range from 1.33% to 5.8% according to the location of the primary cancer and follow up duration. The term 'Synchronous Malignancy' is used when two or more malignancies appear within 6 months whether presenting in same or different organ with a different histology or morphology. Synchronous malignancies like these always carry a diagnostic challenge for the physician. Radiographic imaging collaborated with Histopathology and Immunohistochemistry are mandatory to form final diagnosis. Here we present a case of 56 year old female, known case of urinary bladder presenting with synchronous granulosa cell tumor. To the best of our knowledge, this is the first case of Urothelial carcinoma of the Urinary bladder presenting with synchronous malignancy of Granulosa cell tumor of the Ovary. Treatment in this case was done according to standard guidelines with acknowledgement of possible drug drug interactions.