In Vitro Antioxidant Properties of Novel Schiff Base Complexes
Mohammad Ibrahim, Asif Khan, Muhammad Ikram, Sadia Rehman, Muzamil Shah, Hazrat Un Nabi, Ahamefula A. Ahuchaogu
Asian Journal of Chemical Sciences · pp. 1–12 · Published 15 Apr 2017
10.9734/AJOCS/2017/32244Abstract
Aim: In order to identify and evaluate the metal-derived synthetic antioxidants having high free radicals scavenging capacity related to various disorders has received much interest in last decades. Recently, synthetic antioxidants are widely used instead of natural antioxidants because they are effective and cheaper. Study Design: In the current investigation, a synthesized Schiff base ligand (2-{(E)-[(4-chlorophenyl)imino]methyl}phenol) and their metal complexes (Bis(2-{(E)[(4chlorophenyl) imino]methyl} phenol)nickel(II), Bis(2-{(E)[(4chlorophenyl)imino]methyl}phenol)Cobalt(II), Bis(2-{(E)[(4chlorophenyl)imino]methyl}phenol)copper(II), Bis(2-{(E)-[(4-chlorophenyl)imino]methyl}phenol) zinc(II)) have been evaluated in vitro for their possible antioxidant properties. Place and Duration of Study: Department of chemistry, Abdul Wali Khan University Mardan, Khyber Pakhtunkhwa, Pakistan. The experiment lasted for three days (72 hours). Methodology: The antioxidant activity of the synthesized compounds were screened by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), Ferrous ion chelation (FIC), Ferric reducing antioxidant power (FRAP), Total antioxidant activity (Phosphomolybdenum methods) and Hydroxyl radical (•OH) radical scavenging activity. Results: The synthesized compounds showed significant dose dependent antioxidant activities comparable with that of the classical antioxidants, ascorbic acid and ethylenediaminetetraacetic acid (EDTA). Conclusions: The compounds exhibited are very reactive towards DPPH radicals, OH radicals, and Fe+2 ions and it also actively reduces Fe(III) ion to Fe(II) and Mo(VI) ion to Mo(V) form. The ligand having moderate and all of the metal complexes were existed encouraging results which indicate the importance of Schiff base ligand a metal complexes as a source of synthetic antioxidants and possibly potent drugs.
Cited by 20
Hany M. Abd El-Lateef, Tarek El‐Dabea, Mai M. Khalaf · Antioxidants · 2023
Judith Anane, Esther Owusu, Gildardo Rivera · International Journal of Molecular Sciences · 2024
Solange de Oliveira Pinheiro, Jordana Lima Braga, Wildson Max Barbosa da Silva · Future Medicinal Chemistry · 2025
Judith Anane, Esther Owusu, Gildardo Rivera · 2024
Hammed H.A.M. Hassan, Hend Hussien, Amel F. Elhusseiny · 2022
R. Divya Mohan, S. Sarukrishna, Aparna Surendra Babu · Inorganica Chimica Acta · 2026
Adesola A. Adeleke, Segun D. Oladipo, Robert C. Luckay · ChemistrySelect · 2025
Siddharth Gautam, Khyati Tomar, Sadhna Chauhan · Asian Journal of Organic Chemistry · 2025
M.B. Manu, P. Deepika, N. Srikantamurthy · Asian Journal of Chemistry · 2026
B. Roopashree, B. Mahesh, Ramith Ramu · Journal of Biomolecular Structure and Dynamics · 2023
Related research
- Trace Elements, Antioxidants, Uric Acid, C-Reactive Proteins and Estrogen Levels of Preeclamptic Pregnant Women in Owerri, Nigeria — shares topic coverage
- Effects of Selected Antioxidants on Atherosclerosis in Hyperlipidemic Wistar Rats — shares topic coverage
- Study of Antioxidants Vitamin E and Ascorbic Acid level in Pre-eclampsia and Normotensive Pregnant Women Attending the Antenatal Department of a Rural Hospital in Imo State South East Nigeria — shares topic coverage
- Antioxidant Protection Mechanisms in the Cardiovascular System — shares topic coverage
- Evaluation of Antioxidants, and Haematological Indices in Glaucoma Patients: A Case Study of Bayelsa State, Nigeria — shares topic coverage
Article metrics
Real usage data collected on this platform.
0
Page views
0
PDF downloads
0
Outbound clicks
20
Citations
Views by country
Approximate, from request IP at view time — not citizenship or institution. Countries with fewer than 5 views are grouped as "Other".
No views recorded yet.
Traffic sources
Referring site, by host.
No traffic recorded yet.
Views and downloads exclude known bots/crawlers. Citations combines this platform's own DOI-resolved index with each external source's own reported total — see Cited by above for individually listed citing works. Last refreshed 0 seconds ago.