Bioactive Compounds of the Salivary Glands from Aedes aegypti with Anti-Hemostatic Action
Bruno Marcel Silva de Melo, Norma Luciene Lima da Silva, Rafaelli de Souza Gomes, Kely Campos Navegantes, Ana Lígia de Brito Oliveira, Lorena Almeida, Carolina Heitmann Mares Azevedo, Marta Chagas Monteiro
Annual Research & Review in Biology · pp. 1–17 · Published 24 Aug 2015
10.9734/ARRB/2015/20322Abstract
Blood-sucking arthropods evolved a salivary cocktail of anti-hemostatic, platelet antiaggregant and vasodilators components that neutralize the effects of hemostasis and allow a successful blood supply occurs. In salivary glands from Aedes aegypti was found several components with anti-hemostatic action that inhibit the platelet aggregation and coagulation. These anticoagulants can prevent clot formation during the ingestion and digestion of blood meals by the Ae. aegypti insect. Thus, this review focused in Ae. aegypti saliva components that have anticlotting action and that has potential sources of novel pharmacologically active molecules, as potential therapeutic of new cardiovascular and anti-thrombotic drugs.
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