An Assessment of Analgesic and Anti-inflammatory Activity of Manilkara zapota on Rat Model

Abstract

Background: The word "herbal medicine" refers to using medicinal plants to prevent or treat sickness. This definition encompasses a broad range of practices, from the widespread usage of traditional medicines in every culture to the standardized and titrated extracts of herbs. Aims: In this study, an extract of Manilkara zapota was administered to rats to investigate this plant's analgesic and anti-inflammatory properties. Methods: The carrageenan-induced acute inflammation technique was used to test the anti-inflammatory activity, and the acetic acid writhing and Tail-flick method was used to evaluate the analgesic efficacy. Results: Regarding the anti-inflammatory action, the 1,000 mg/kg dosage extract was the only one that exhibited a highly significant (p < 0.05) result. In contrast, the other doses didn't show any statistically significant difference. None of the groups showed statistically significant results using the acetic acid writhing technique in this test. The Tail-flick technique showed that a 1,000 mg/kg dose was statistically significant (p < 0.05) at both the 3 and 4 h time periods. The results took just 4 hours after the 750 mg/kg dosage to reach statistical significance (p < 0.05). Conclusion: According to these findings, M. zapota exhibits both analgesic and anti-inflammatory efficacy when tested on rat models.