Anticolorectal Cancer Properties of Some Flavonoids and Terpenoids from African Propolis via Molecular Docking

Abstract

Propolis, a resinous material produced by bees from plant exudates, has long been reported to be used in traditional herbal medicine and is widely consumed as a health aid and immune system booster. The colorectal cancer which is a world health emergency has renewed interest in propolis products worldwide. Fortunately, various aspects of the Poly adenosine diphosphate ribose polymerases (PARPs) mechanism are potential targets for propolis compounds. The treatment of Colerectal cancer (CRC) has been focused on the tumor site and stage of the disease using chemotherapy or radiotherapy, surgery, hormonal therapy, immunotherapy etc. Although apoptosis is being used in preventing damaged cells from developing out but due to secondary mutations in apoptosis-regulating gene, it can distort this order. This work aimed at evaluating the anticancer potential of some flavonoids and terpenoids from African propolis which can inhibit the protein of PARPs therefore preventing the growth of the cancer cell. From the result β- amyrin and naringin showed the best binding affinity and fit at -11.9 kcal/mol and -11.7 kcal/mol respectively which were better than standard drugs Irinotecan -11.2 kcal/mol and Doxorubicin -9.1 kcal/mol with the ligand at -11.2 kcal/mol. Other compounds also showed very high binding affinity of more than -9.0 kcal/mol suggesting the propolis compounds as potential anticancer compounds.