Synthesis of Some New 4-[2-(2-methylbenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives with Their Antioxidant Properties

Abstract

Aims: To synthesize heterocycylic Schiff bases and evaluate their antioxidant activity. Study Design: Synthesizing some new 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives and determining their chemical structure via IR and NMR spectroscopy. The synthesized new compounds were analyzed for their in vitro potential antioxidant activities. Place and Duration of Study: Department of Chemistry, Kafkas University, Kars, Turkey. Between February 2014 to February 2015. Methodology: Nine new 3-alkyl(aryl)-4-[2-(2-methylbenzoxy)-benzylidenamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized by the reactions of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 2-(2-methylbenzoxy)-benzaldehyde (2) which had also been synthesized by the reactions of 2-hydroxybenzaldehyde with 2-methylbenzoyl chloride by using triethylamine. Results: Schiff bases were synthesized and their structures were determined with spectral methods. Antioxidant evaluation were carried out and discussed. Conclusion: Synthesis and structural determination of the new 3-alkyl(aryl)-4-[2-(2-methylbenzoxy)-benzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) was successfully done. The antioxidant evaluation was determined.