Comorbidities Associated with Psoriasis: A Single Center Study of Morocco

Abstract

Introduction: Psoriasis, a chronic autoimmune inflammatory disease, is recognized as a systemic inflammatory disease with cutaneous and extracutaneous manifestations, often associated with multiple comorbidities. Our study aims to identify the various comorbidities associated with psoriasis, determine their prevalence, and better understand the systemic nature of the disease in Moroccan patients Materials and Methods: We conducted a prospective study in the dermatology department of the Ibn Sina University Hospital in Rabat, Morocco, between June 2021 and June 2022.  we included 150 patients who were diagnosed with mild, moderate, or severe psoriasis. Results: 150 patients with psoriasis were enrolled during this period, with 77% cases of mild to moderate psoriasis and 23% of severe psoriasis. The sex ratio was 0.73, and the average age was 43.9 years. Comorbidities were dominated by metabolic syndrome (33.33%) in the lead, followed by autoimmune diseases (29.33%), cardiovascular diseases (24%), rheumatological diseases (18%), dermatological diseases (9%), or tumor pathologies (9%), infectious diseases (9%), smoking and alcohol consumption (9%), stress and psychiatric disorders (6%), and other diseases (6%). Conclusion: This study encompasses the comorbidities associated with psoriasis in a Moroccan population. These comorbidities are diverse, with a predominant presence of metabolic syndrome, cardiovascular diseases, and thyroid disorders. A multicenter study involving a larger number of patients would be desirable.