Determination of VASA and IFITM3 Immunolocalization in Experimental Hyperthyroidism in Rat Ovaries at the Stage of Diestrus
Serpil Ünver Saraydın, Kübra Başol, Dursun Saraydın
Asian Journal of Pregnancy and Childbirth · pp. 18–27 · Published 27 Feb 2023
Abstract
Aims: Hyperthyroidism occurs due to overproduction of thyroid hormone. We aim to investigate the relationship of VASA and IFITM3 with hyperthyroidism by demonstrating immunolocalization at the stage of diestrus in hyperthyroid rat ovaries. Materials and Methods: To induce hyperthyroidism, rats were given 250 ug/kg/day of L-thyroxine by subcutaneous injection for 21 days. The control group was a saline solution injected only. Ovarian tissues of euthanized rats were removed after cardiac blood was collected. Results: It was determined that VASA is intensely expressed in oocytes and theca layers of growing follicles, and IFITM3 is strongly expressed in germinal epithelium and oocytes. Conclusion: The intense expression of VASA is most likely due to the abundant ATP in the mitochondria of the oocyte cytoplasm. The effect of VASA and IFITM3 expressions in hyperthyroidic ovary compared to the control group shows the link between hyperthyroidism and follicle development.
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