Investigation Chemical Interaction Type of Polyacrylic Acid Based Hydrogel with Doxorubicin Hydrochloride

Abstract

In alkali environment hydrogels with high swelling ability have been synthesized as a result of cross-linking  well water soluble and non-toxic polymer - polyacrylic acid (Mη=230 kDa) with 5, 10, 15 and 20% ratio (by weight) of N,N`-methylene-bis-acrylamide. Absorption processes of obtained hydrogels with doxorubicin hydrochloride from water environment have been researched. Dependence of sorption degree and sorption capacity of antibiotic on environment pH and starting concentration of doxorubicin has been researched and nature of chemical interaction between hydrogel and antibiotic has been found out via infrared, ultraviolet, nuclear-magnet resonance spectroscopy methods. It was determined that in pH=8 hydrogel taking 10% cross-linking reagent inside has 570% swelling degree and with increasing environment pH sorption capacity increases up to 13.4 mg/g as per doxorubicin of gel. It was investigated with UV, FTIR and NMR spectroscopy methods that interaction hydrogel with antibiotic occurs due to hydrogen bonds and electrostatic forces.