This review paper describes the different synthetic routes used for the synthesis of substituted phthalazine derivatives. Phthalazines have been used as building blocks for the synthesis of a new molecule with heterocyclic structure. These new molecules are highly useful in medic...
Open access
Research Article10.9734/jpri/2019/v27i630189
Sameer E. Al-harthy, Mashael S. Al-Motairi, Huda M. Al-Kreathy, Fatemah O. Kamel, Mohamed M. Sayed-Ahmed, Etimad Abbas Huwait, Hamdan S. Al-Malkey & Abdel-Moneim M. Osman·Journal of Pharmaceutical Research International·2019
Background: Worldwide, breast cancer is a main cause of morbidity and mortality in females. Doxorubicin (DOX) is an anthracycline anticancer drug and most commonly employed in polychemotherapy protocols in the treatment of solid and hematological tumors. Unfortunately, its optima...
Open access
Research Article10.9734/jpri/2019/v27i630188
Aim: To evaluate the combined and individual effects of thioxanthene containing antipsychotic and anti-platlet drug on Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) in rats. Methods: This investigational study comprised of 100 albino rats of both sexual orienta...
Open access
Research Article10.9734/jpri/2019/v27i630187
Type 2 diabetes (T2DM) is a metabolic disorder disease and DPP-4 inhibitors are a class of oral hypoglycemic that blocks the dipeptidyl peptidase-4 (DPP-4) enzyme. DPP-4 inhibitors reduce glucagon and blood glucose levels and don’t have side effects such as hypoglycemia or weigh...
Open access
Research Article10.9734/jpri/2019/v27i630186
Computational chemistry is a unique method in the drug discovery process?? Explain Why?. In this study 109 molecules containing the isatin backbone were subjected to quantitative structure-activity relationship analysis to find the structure requirements for ligand binding. The s...
Open access
Research Article10.9734/jpri/2019/v27i530184
Background: Because advance knowledge of fetal sex can satisfy parental curiosity and allay anxiety, attempts at its determination prior to birth have a long history. There may also be reason to determine fetal sex when sex-specific genetic disorders are suspected. The aim of thi...
Open access
Research Article10.9734/jpri/2019/v27i530183
Background: Asthma as a chronic disease may affect the growth process. The aim of this study was to investigate the anthropometric indices in 2-18 years old children with asthma and compare them with the control group. Patients and Methods: In a case-control study, 150 asthmatic...
Open access
Research Article10.9734/jpri/2019/v27i530181
Background and Objectives: By knowing the level of knowledge of triage nurses, we will be capable of making the right decision about allocating suitable resources for enriching the quality of the emergency department. So, the objective of our study is to evaluate triage knowledge...
Open access
Research Article10.9734/jpri/2019/v27i530182
Objective: Postoperative infections of the central nervous system are common complications of neurological surgeries, which can lead to bad consequences for the patient and increase the cost of treatment. Incorrect diagnosis or treatment of meningitis after craniotomy can lead to...
Open access
Research Article10.9734/jpri/2019/v27i530180
Background: Warts are very common disorders. Plane warts are caused by Human Papilloma Virus (HPV) occurring mostly in children and young adults. Among the treatment modalities, topical application of trichloroacetic acid (TCA) is age old. Potassium hydroxide (KOH) has a keratoly...
Open access
Research Article10.9734/jpri/2019/v27i430178